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| Name | Class |
|---|---|
| Owlstone Ltd | INDUSTRY |
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The project aims to increase the diagnostic accuracy in occupational asthma (OA), with emphasis on Irritant Induced Asthma (IIA). Currently, most patients are evaluated in occupational medicine by comparing the exposure and symptom characteristics with epidemiological data. Biological markers may be present in AA, but presently not in IIA. The majority of cases evaluated are considered as possible IIA, i.e. low-dose multiple exposures. VOC features will be analyzed with the Breath Biopsy® and TD-GS-MS (Owlstone Medical Ltd, UK).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Occupational Asthma | Patients refered for assesment of occupational asthma |
| |
| Respiratory Healthy Control | Employees at Oslo University Hospital |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Breath Biopsy | Device | ReCIVA breath sampler (Owlstone Medical, Cambridge, UK) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Discovery of VOC Biomarkers in Asthma | To evaluate the sensitivity, specificity, positive and negative predictive value of VOC biomarkers in exhaled breath samples to identify asthma. | Baseline |
| Discovery of VOC Biomarkers in Occupational Irritant Asthma | To evaluate the sensitivity, specificity, positive and negative predictive value of VOC biomarkers in exhaled breath samples to identify irritant asthma after occupational exposures. | Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with occupational asthma, referred to the Unit of Environmental and Occupational medicine OUS for evaluation of OA.and healthy volunteers
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bato Hammarström, MD/PhD | Contact | +47 230 16667 | bato.hammarstrom@ous-hf.no | |
| Tonje Trulssen Hildre, M.Sc. | Contact | tohild@ous-hf.no |
| Name | Affiliation | Role |
|---|---|---|
| Bato Hammarstrøm, MD/PhD | Oslo University Hospital | Principal Investigator |
| Tonje Trulssen Hildre, M.Sc. | Oslo University Hospital | Study Chair |
| Hilde Heiro, MD |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oslo University Hospital | Recruiting | Oslo | Norway |
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| ID | Term |
|---|---|
| D059366 | Asthma, Occupational |
| ID | Term |
|---|---|
| D001249 | Asthma |
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D012130 | Respiratory Hypersensitivity |
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Volatile Organic Compounds (VOC) in exhaled air
| Oslo University Hospital |
| Study Chair |
| Britt G Randem, MD/PhD | Oslo University Hospital | Study Chair |
| D006969 |
| Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D009784 | Occupational Diseases |