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| Name | Class |
|---|---|
| Samsung Semiconductor R&D center | UNKNOWN |
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Although the effect of interaction between genetic and environmental factors on body fat mass (BFM) has been proposed, how lifestyle changes affect body weight with regard to the genetic composition needs to be verified. The investigators designed an observational study, consisting of healthy adults with single nucleotide polymorphism (SNP) genotyping and longitudinal monitoring of lifestyle including food consumption and physical activities. The investigators recruited the participants who desired to control their body fat mass. Participants freely choose one of the options among carbohydrate intake reduction, fat intake reduction or exercise amount increment to control their body fat mass. Their lifelog on exercise and diet were collected, using a wearable device, for three months. Further, the investigators assessed anthropometric and serologic markers to measure the effect of participant's lifestyle modification. The investigators evaluate the influence of genetic compositions on body fat reduction induced by lifestyle change. Four different genome-wide polygenic scores (GPS) of volunteers are calculated to test the genetic effects of each modification. In this lifestyle observational study, the investigators expect to validate the interaction of genetic and environmental factors in determining BFM, and implicate the healthcare utility of lifestyle modifications using personalized and genomic perspective.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Carbohydrate reduction group | Participants chose to control their body fat mass by reducing their carbohydrate intake through observation study periods. |
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| Fat reduction group | Participants chose to control their body fat mass by reducing their fat intake through observation study periods. |
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| Intense exercise group | Participants chose to control their body fat mass by vigorously increasing the time and intensity of exercise through observation study periods. |
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| Moderate exercise group | Participants chose to control their body fat mass by moderately increasing the time and intensity of exercise through observation study periods. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lifestyle | Behavioral | Participants who desire to control body fat mass chose the one of lifestyle modification on their diet or exercise. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change of body fat mass | Anthropometric data including body fat mass were measured by InBody720 --assessing whole and segmental body composition. | baseline and 14 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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Participants are all lived in South Korea in Seoul and Kyeonggi-do.
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| Name | Affiliation | Role |
|---|---|---|
| Woong-Yang Park, MD | Samsung Genomic Institute | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samsung Medical Center | Seoul | 06351 | South Korea |
A plan is undecided yet.
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