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In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain.
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain. The investigators will select 8 relevant diagnostic categories: traumatic brain injury, major depressive disorder, bipolar disorder, schizophrenia, attention deficit hyperactivity disorder, borderline personality disorder and substance use disorder. The study will also include a cohort of healthy controls for comparison.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Traumatic Brain Injury | Experimental | This group consists of individuals diagnosed with traumatic brain injury. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized. |
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| Major Depressive Disorder | Experimental | This group consists of individuals diagnosed with major depressive disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized. |
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| Bipolar Disorder | Experimental | This group consists of individuals diagnosed with bipolar disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized. |
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| Schizophrenia | Experimental | This group consists of individuals diagnosed with schizophrenia. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized. |
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| Attention Deficit Hyperactivity Disorder |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Direct Current Stimulation | Device | In tDCS, electrodes are applied on the scalp to transmit direct current at low current amplitudes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in N-Back Task | Working Memory Task | Baseline to Post-Treatment, 1 Week |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Flanker Task | Attention and Inhibitory Control Task | Baseline to Post-Treatment, 1 Week |
| Change in Multi-Source Interference with International Affective Picture System Task | Cognitive Control During Emotional Regulation Task |
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Inclusion Criteria
Exclusion Criteria
Contraindication to tDCS: history or epilepsy, metallic implants in the head and neck, brain stimulators, vagus nerve stimulators, shunts, pacemakers, pregnancy.
Active substance dependence (except for tobacco and cannabis).
Pregnant or nursing females.
Inability to participate in testing procedures.
Additional exclusion criteria for healthy controls:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Joan Camprodon, MD, PhD, MPH | Contact | 6177265348 | ||
| Patricia Cirillo, MD, PhD | Contact | 6177243217 |
| Name | Affiliation | Role |
|---|---|---|
| Joan Camprodon, MD, PhD, MPH | Massachusetts General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Massachusetts General Hospital | Recruiting | Boston | Massachusetts | 02129 | United States |
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This group consists of individuals diagnosed with attention deficit hyperactivity disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized. |
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| Borderline Personality Disorder | Experimental | This group consists of individuals diagnosed with borderline personality disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized. |
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| Substance Use Disorder | Experimental | This group consists of individuals diagnosed with substance use disorder. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized. |
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| Healthy Controls | Active Comparator | This group consists of individuals diagnosed with healthy controls. This group will undergo three sessions of tDCS: two active sessions and one sham session. The order of the sessions is randomized. |
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| Baseline to Post-Treatment, 1 Week |
| Change in Delayed Discounting Task | Decision-Making Task | Baseline to Post-Treatment, 1 Week |
| Change in Stop Signal Task | Ability to Inhibit a Response Task | Baseline to Post-Treatment, 1 Week |
| Change in Iowa Gambling Task | Risk-Taking Task | Baseline to Post-Treatment, 1 Week |
| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| D003865 | Depressive Disorder, Major |
| D001714 | Bipolar Disorder |
| D012559 | Schizophrenia |
| D001289 | Attention Deficit Disorder with Hyperactivity |
| D001883 | Borderline Personality Disorder |
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D003866 | Depressive Disorder |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
| D000068105 | Bipolar and Related Disorders |
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D019958 | Attention Deficit and Disruptive Behavior Disorders |
| D065886 | Neurodevelopmental Disorders |
| D010554 | Personality Disorders |
| D064419 | Chemically-Induced Disorders |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |
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