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This study will examine the possible effects of tDCS (Transcranial Direct Current Stimulation) treatment to the left DLPFC on cognitive functions which were found to be deficient amongst ADHD patients. The study will include 100 subjects, 50 of whom diagnosed with ADHD. Subjects will complete the ASRS questionnaire to measure ADHD symptoms severity. Next, subjects will complete a series of cognitive tasks, after which they will receive either tDCS treatment or a sham treatment. Finally, subjects will repeat the cognitive tasks. Later that day, a telephonic follow up will take place. ADHD symptoms will be assessed again the next day.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ADHD tDCS | Experimental |
| |
| ADHD Sham | Sham Comparator |
| |
| Healthy control tDCS | Experimental |
| |
| Healthy control Sham | Sham Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Direct Current Stimulation | Device | To stimulate the left DLPFC, the anode electrode will be placed over F3 and the cathode will be placed over F4. Each stimulation will be applied for 20 min at 2mA intensity. |
| Measure | Description | Time Frame |
|---|---|---|
| N-back | change in working memory: increase in hit rate | through study completion |
| Stroop | change in interference control: smaller interference effect | through study completion, up to 1 hour after treatment |
| Stop-signal | change in response inhibition: shorter SSRT | through study completion, up to 1 hour after treatment |
| Time Reproduction task | change in time perception: increased accuracy | through study completion, up to 1 hour after treatment |
| Continuous Performance Task | change in continuous concentration: increase in accuracy | through study completion, up to 1 hour after treatment |
| Navon task | change in accuracy, shorter RT's | through study completion, up to 1 hour after treatment |
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Inclusion Criteria:Participation criteria for healthy participants
Participation criteria for ADHD diagnosed participants
ADHD diagnosis (according to DSM V).
Right hand dominance.
Participants must be able to comprehend the study's procedure and sign an informed consent.
Participants who regularly use Methylphenidate will be required to avoid the medication for 24 hours prior to study and 12 hours post study.
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Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hebrew University of Jerusalem | Jerusalem | Israel |
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| Sham | Device | For the sham treatment, stimulation will be stopped after 30 seconds. Current will be renewed five times throughout the session for 2 seconds each time, to mimic the tDCS stimulation. |
|
| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |
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