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The feasibility and efficacy of emergency curative resection of complicated colorectal cancer is still controversial. This prospective study aim is to assess surgical and oncologic outcomes after emergency compared to elective curative resection of colorectal cancer
60 consecutive patients presented with complicated colorectal cancer managed by emergency surgery were included and compared to another 155 consecutive patients admitted during the same period with uncomplicated colorectal cancer managed by elective surgery. Both groups were compared regarding curative resection rate, early postoperative mortality and morbidity, 3-years tumor recurrence and survival rates.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Emergency group | Patients presented to emergency by complicated colorectal cancer ( Obstruction, bleeding or perforation) |
| |
| Elective group | Patients presented with uncomplicated colorectal cancer for resection treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Curative resection of colorectal cancer | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Adequate oncologic resection | Negative resection margins + adequate lymphadenectomy ( Lymph Nodes retrieved > 12) | histopathological assessment of surgical specimens within 2 weeks postoperative |
| early postoperative mortality after curative resection of colorectal cancer | early death due to cause related to surgery | within 90 days after surgery |
| early postoperative morbidity after curative resection of colorectal cancer | surgery-related complications | within 90 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Tumor recurrence | either local or distant | By the end of the 3 years follow up period |
| Disease free survival | % of patients survived without recurrence |
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Inclusion Criteria:
Exclusion Criteria:
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This study included 60 consecutive patients presented by complicated colorectal cancer treated by emergency surgery at Alexandria University hospital between January 2015 and January 2017 (Group I). Another 155 patients with uncomplicated colorectal cancer treated by elective surgery during the same period were included (Group II).
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| Name | Affiliation | Role |
|---|---|---|
| Mohamed Elmessiry, MD, PhD | Ass. Professor of Surgery | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23758762 | Background | Ghazi S, Berg E, Lindblom A, Lindforss U; Low-Risk Colorectal Cancer Study Group. Clinicopathological analysis of colorectal cancer: a comparison between emergency and elective surgical cases. World J Surg Oncol. 2013 Jun 11;11:133. doi: 10.1186/1477-7819-11-133. | |
| 15820446 | Background | Biondo S, Marti-Rague J, Kreisler E, Pares D, Martin A, Navarro M, Pareja L, Jaurrieta E. A prospective study of outcomes of emergency and elective surgeries for complicated colonic cancer. Am J Surg. 2005 Apr;189(4):377-83. doi: 10.1016/j.amjsurg.2005.01.009. |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D004630 | Emergencies |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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Surgical specimens after curative resection of colorectal cancer
| By the end of the 3 years follow up period |
| Overall survival | % of all patients survived either with or without recurrence | By the end of the 3 years follow up period |
| 17983065 | Background | Kim J, Mittal R, Konyalian V, King J, Stamos MJ, Kumar RR. Outcome analysis of patients undergoing colorectal resection for emergent and elective indications. Am Surg. 2007 Oct;73(10):991-3. |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |