High Resolution Imaging for Analysis of MVNT

High Resolution Imaging for Analysis of Multinodular and Vacuolating Neuronal Tumor of the Cerebrum

MVNT (multinodular and vacuolating neuronal tumor of the cerebrum) is a benign, recently discovered, neuronal lesion, the incidence of which is unknown.

It seems to predominate in the temporal lobes and presents a characteristic MRI appearance: multiple subcortical nodules, developed at the white substance / gray substance junction, of variable size, well limited, in iso-hyposignal T1, hypersignal T2 and hypersignal FLAIR.

The articles describing this entity report the lack of scalability in MRI during patient monitoring, going in the direction of the benignity of the lesion.

The diagnosis sometimes remains uncertain with current MRI sequences, and the patient risks undergoing invasive surgery to remove a lesion that is actually benign. Hence the importance of developing the most precise diagnostic criteria possible. The contribution of advanced MRI techniques, such as ultra-high resolution sequences in the characterization of these lesions, has not yet been studied.

Inclusion Criteria:

• Patient over 18 years of age

• Prospective inclusion of all patients with suspected MVNT on a first exploratory MRI: at least the 2 major criteria associated with at least 1 minor criterion will be required to fit into the definition of suspected MVNT:

  • Major criteria :

    • Multinomodular clustered appearance
    • Franc hypersignal FLAIR/T2

  • Minor criteria :

    • No mass effect
    • Hyposignal T1

• Having received informed information about the study and having given express consent to participate in the study

Exclusion Criteria:

• Contraindication to MRI
• Patient benefiting from a legal protection measure
• Pregnant or breastfeeding woman

Secondary exclusion criteria:

- No characterization MRI done