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This is a prospective study to validate an algorithm for predicting the effect of orthokeratology on myopia progression in children from 8 hospitals in China.
Orthokeratology (ortho-K) is thought to be an effective way to control the progression of Myopia in children, but its effectiveness may vary among different individuals. The investigators therefore conducted a prospective, multi-center study to use an algorithm to predict the progression of myopia among Chinese children wearing Orthokeratology lenses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Children with myopia | A total of 1,000 children from 8 hospitals in China is required to undergo ophthalmic examinations and complete questionnaires at baseline and 1yr after wearing ortho-k lenses. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Orthokeratology lenses | Device | Orthokeratology lenses |
|
| Measure | Description | Time Frame |
|---|---|---|
| AUROC of the prediction algorithm for identifying fast progressing myopes | Age-specific axial length (AL) changes previously described by Wang et al.(IOVS, 52 (11), 7949-53, 2011) are used as cut-off values to determine whether a child is a fast progressor or not. A child whose AL change falls on or above the cut-off value is considered to be a fast progressor. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Sensitivity and specificity of the prediction algorithm for identifying fast progressing myopes | The investigators will estimate sensitivity and specificity of the predictive algorithm for identifying fast progressing myopes. | 1 year |
| Performance of an algorithm for predicting AL |
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Inclusion Criteria:
Exclusion Criteria:
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1,000 children from 8 hospitals in China plan to wear orthokeratology lenses for myopia control.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xialin Liu, M.D. Ph.D. | Contact | +8613719109851 | liuxialin@gzzoc.com |
| Name | Affiliation | Role |
|---|---|---|
| Xialin Liu, M.D. Ph.D. | Zhongshan Ophthalmic Center, Sun Yat-sen University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hefei Bright Eye Hospital | Recruiting | Hefei | Anhui | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21896861 | Background | Wang D, Ding X, Liu B, Zhang J, He M. Longitudinal changes of axial length and height are associated and concomitant in children. Invest Ophthalmol Vis Sci. 2011 Oct 10;52(11):7949-53. doi: 10.1167/iovs.11-7684. |
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| ID | Term |
|---|---|
| D009216 | Myopia |
| ID | Term |
|---|---|
| D012030 | Refractive Errors |
| D005128 | Eye Diseases |
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The investigators will use mean absolute error (MAE), R square to evaluate the performance. |
| 1 year |
| Performance of an algorithm for predicting spherical equivalent refractive error | The investigators will use mean absolute error (MAE), R square to evaluate the performance. | 1 year |
| Zhongshan Ophthalmic Center (Haizhu Branch), Sun Yat-sen University | Recruiting | Guangzhou | Guangdong | China |
|
| Wuhan Bright Eye hospital | Recruiting | Wuhan | Hubei | China |
|
| Nanchang Bright Eye Hospital | Recruiting | Nanchang | Jiangxi | China |
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| Jinan Bright Eye Hospital | Recruiting | Jinan | Shandong | China |
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| Shanghai Bright Eye Hospital | Recruiting | Shanghai | Shanghai Municipality | China |
|
| Chengdu Bright Eye Hospital | Recruiting | Chengdu | Sichuan | China |
|
| Kunming Bright Eye hospital | Recruiting | Kunming | Yunnan | China |
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