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This is a prospective study to validate a predictive algorithm for identifying fast progressing myopes.
Orthokeratology (ortho-K) has been demonstrated to slow myopic progression and reduce axial elongation in young patients, but this treatment is limited by the need for contact lens wear, which is the common cause for keratitis in children, and therefore cautious use is recommended. There is a need to identify the patients that could benefit most from this treatment. In order to do so, we conduct a retrospective study and create a large database (n = 10,000) of de-identified data to train an algorithm for identifying fast progressing myopes. In addition, we will perform a prospective study to validate this predictive algorithm and determine the effectiveness of Orthokeratology among different individual patients in China.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Children with myopia | A total of 3,000 children from Zhongshan Ophthalmic Center is required to undergo ophthalmic examinations and complete questionnaires at baseline and 1yr after wearing Ortho-K. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Orthokeratology lenses | Device | Orthokeratology lenses |
|
| Measure | Description | Time Frame |
|---|---|---|
| AUROC of the prediction algorithm for identifying fast progressing myopes | Age-specific axial length (AL) changes previously described by Wang et al.(IOVS, 52 (11), 7949-53, 2011) are used as cut-off values to determine whether a child is a fast progressor or not. A child whose AL change falls on or above the cut-off value is considered to be a fast progressor. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Sensitivity and specificity of the prediction algorithm for identifying fast progressing myopes | The investigators will estimate sensitivity and specificity of the predictive algorithm for identifying fast progressing myopes. | 1 year |
| Performance of an algorithm for predicting AL |
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Inclusion Criteria:
Exclusion Criteria:
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3,000 children from Zhongshan Ophthalmic Center plan to wear orthokeratology lenses for myopia control.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yingfeng Zheng, M.D. Ph.D. | Contact | +8613922286455 | zhyfeng@mail.sysu.edu.cn |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhognshan Ophthalmic Center (Zhujiang New Town Branch), Sun Yat-sen University | Recruiting | Guangzhou | Guangdong | 510000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21896861 | Background | Wang D, Ding X, Liu B, Zhang J, He M. Longitudinal changes of axial length and height are associated and concomitant in children. Invest Ophthalmol Vis Sci. 2011 Oct 10;52(11):7949-53. doi: 10.1167/iovs.11-7684. |
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| ID | Term |
|---|---|
| D009216 | Myopia |
| ID | Term |
|---|---|
| D012030 | Refractive Errors |
| D005128 | Eye Diseases |
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The investigators will use mean absolute error (MAE), R square to evaluate the performance. |
| 1 year |
| Performance of an algorithm for predicting spherical equivalent refractive error | The investigators will use mean absolute error (MAE), R square to evaluate the performance. | 1 year |