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Alzheimer's disease (AD) is a prevalent, long-term progressive degenerative disorder with great social impact. It is currently thought that, in addition to neurodegeneration, vascular changes also play a role in the pathophysiology of the disease. Meantime, EEG resting state has also demonstrated significant change in patients with AD in neuroscience research area. Thus, the combination of these sensitive biomarkers would lead to a potential new biomarker for detection of AD, which has higher specificity and sensitivity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| mild cognitive impairment (MCI) | observational |
| |
| Patients with mild to moderate AD | observational |
| |
| Normal controls | observational |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| observational | Diagnostic Test | No intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| OCT retinal and choroidal thickness | retinal structural anatomy | 2 days |
| Retinal Photography vascular caliber | use Retinal Photography to detect vascular caliber | 2 days |
| functional connection strength in the brain network | record resting-state EEG, use graph theory to calculate the functional connection strength | 7 days |
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Inclusion Criteria:
Exclusion Criteria:
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We would recruit three groups of elders. One is the control group without cognitive impairment, one is the aMCI group which is deemed as the pre-stage of AD, and also the AD group.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jin Yuan, phD | Contact | 13825141659 | yuanjincornea@126.com | |
| Li Gu, phD | Contact | +8615889937313 | guli7@mail2.sysu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Jin Yuan, phD | Zhongshan Ophthalmological Center, Sun Yat-sen University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongshan Ophthalmic Center | Guangzhou | Guangdong | 510000 | China |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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