Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Aveiro University | OTHER |
| Hospital Infante D. Pedro, Centro Hospitalar Do Baixo Vouga | UNKNOWN |
| Hospital Pedro Hispano, ULS Matosinhos | UNKNOWN |
| Universidade do Porto |
Not provided
Not provided
Not provided
Not provided
New data suggests that isometric handgrip training (IHT) might become a novel tool in the treatment of hypertension. The main purpose of this research project is to evaluate the effects of home-based IHT on ambulatory blood pressure in older adults with pre-hypertension and hypertension. Eighty-four older adults with pre-hypertension and hypertension will be randomly distributed to one of three groups: home-based IHT, home-based aerobic exercise training (AET), or attention-control group (CON). Each intervention will have a total duration of 8 weeks. At baseline and after completing the intervention, patients will undergo the following evaluations: 24-hour ambulatory blood pressure, cardiorespiratory fitness, endothelial function, damage and repair, arterial stiffness, inflammatory biomarkers, autonomic function, physical activity levels, dietary intake and quality of life. A qualitative analysis will also be applied to enhance the understanding of the efficacy of this intervention from the patient's perspective.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Isometric Handgrip Training | Experimental | The 8-week exercise program will include three sessions of isometric handgrip training per week |
|
| Aerobic Exercise Training | Active Comparator | The 8-week exercise program will include three sessions of aerobic exercise per week |
|
| Control Group | No Intervention | The control group will receive usual medical care |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Isometric Handgrip Training | Other | The 8-week exercise program will include three sessions of isometric handgrip training per week |
|
| Measure | Description | Time Frame |
|---|---|---|
| 24h ambulatory blood pressure | Change from baseline to 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| Arterial Stiffness | Assessed by application tonometry using carotid-femoral pulse wave velocity as the gold-standard measure | Change from baseline to 2 months |
| Endothelial function | Assessed by brachial artery dilation to endothelial-dependent stimuli using an ultrasound, according to the recommendations |
Not provided
Inclusion Criteria:
-
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Alberto J Alves, PhD | CIDESD, University Institute of Maia, Maia, Portugal | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Connecticut | Storrs | Connecticut | 06269 | United States | ||
| Unidade de Saúde Familiar de Santa Joana |
Not provided
| OTHER |
| University of Connecticut | OTHER |
| Unidade de Saúde Familiar de Santa Joana | UNKNOWN |
| Research Center in Sports Sciences, Health Sciences and Human Development | OTHER |
| Unidade de Saúde Familiar Serzedelo | UNKNOWN |
Not provided
Not provided
Not provided
Not provided
| Aerobic Exercise Training | Other | The 8-week exercise program will include three sessions of aerobic exercise per week |
|
| Change from baseline to 2 months |
| Inflamamtion | Plasma levels of inflammatory and anti-inflammatory biomarkers including C-reactive protein, Interleukin-10, total nitric oxide and nitrate/nitrite, endothelial Nitric Oxide Synthase | Change from baseline to 2 months |
| Endothelial cell repair/damage | Assessed by the circulating number of endothelial progenitor cells and circulating endothelial cells in a peripheral blood by flow cytometry. | Change from baseline to 2 months |
| Health-related quality of life | Assessed by the Short-Form 36 | Change from baseline to 2 months |
| Aerobic fitness | Assessed by Chester Step Test | Change from baseline to 2 months |
| Weekly physical activity sleep quality | Measured in seven consecutive days by accelerometry | Change from baseline to 2 months |
| Intervention quality | Assessed by focus group interviews using semi-structured guide with the participants of the experimental groups | two weeks after the intervention |
| Sleep quality | Measured in seven consecutive days by accelerometry | Change from baseline to 2 months |
| Santa Joana, Aveiro |
| Aveiro District |
| 3810-164 |
| Portugal |
| University Institute of Maia | Maia | Porto District | 4475-690 | Portugal |
| Hypertension Unit, Hospital Pedro Hispano, ULS, Matosinhos, Portugal | Matosinhos Municipality | Porto District | 4450-113 | Portugal |
| Hospital Infante D. Pedro, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal | Aveiro | 3810-096 | Portugal |
| Institute of Biomedicine | Aveiro | 3810-193 | Portugal |
| University of Aveiro | Aveiro | 3810-193 | Portugal |
| Unidade de Saúde Familiar Serzedelo | Guimarães | 4765-546 | Portugal |
| CINTESIS, Faculty of Medicine, Porto, Portugal | Porto | 4200-450 | Portugal |
| Reserach Center in Sports Sciences, Health Sciences and Human Development | Vila Real | 5001-801 | Portugal |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| D058246 | Prehypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
Not provided
Not provided