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Recent meta-analyses suggest isometric resistance training (IRT) may be superior to aerobic exercise for lowering blood pressure. The investigators intend to conduct the largest, longest, prospective, double-blind randomized controlled trial using isometric resistance training to reduce blood pressure to reduce hypertension.
We are looking to assess the effect of isometric exercise on ambulatory blood pressure in participants aged 40-70 years who are either pre- or mild hypertensive; either un-medicated or taking medication to control their blood pressure. Our secondary aims are to examine whether the size of blood pressure change is different in those people taking or not taking anti-hypertensive medication, to determine the anti-hypertensive mechanism to IRT, and to establish rate of de-training effects after participants have ceased IRT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IHG 5% Un-medicated | Sham Comparator | Participants with high blood pressure (greater than 120/80) who are not medicated for blood pressure control will conduct isometric handgrip (IHG) exercise at 5% of their maximum voluntary contraction (MVC). Isometric resistance training will be conducted three times a week for 12 weeks, with participants conducting 4 x 2min IHG exercises at each session. |
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| IHG 5% BB | Sham Comparator | Participants with high blood pressure (greater than 120/80) who are currently taking beta blockers for blood pressure control will conduct isometric handgrip exercise at 5% of their maximum voluntary contraction (MVC). Isometric resistance training will be conducted three times a week for 12 weeks, with participants conducting 4 x 2min IHG exercises at each session. |
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| IHG 30% Un-medicated | Experimental | Participants with high blood pressure (greater than 120/80) who are not medicated for blood pressure control will conduct isometric handgrip exercise at 30% of their maximum voluntary contraction (MVC). Isometric resistance training will be conducted three times a week for 12 weeks, with participants conducting 4 x 2min IHG exercises at each session. |
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| IHG 30% BB | Experimental | Participants with high blood pressure (greater than 120/80) who are currently taking beta blockers for blood pressure control will conduct isometric handgrip exercise at 30% of their maximum voluntary contraction (MVC). Isometric resistance training will be conducted three times a week for 12 weeks, with participants conducting 4 x 2min IHG exercises at each session. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Isometric resistance training | Other | Isometric handgrip exercise using a hand dynamometer |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in systolic and diastolic blood pressure | Change measures: baseline and 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Compare and contrast change in systolic and diastolic blood pressure of medicated and un-medicated participants | Baseline and 12 weeks | |
| Detraining effects, changes in systolic and diastolic blood pressure after cessation of Isometric Resistance Training |
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Inclusion Criteria:
Exclusion Criteria:
Younger than 30yrs and older than 70 yrs;
unable to voluntary participate;
unable to participate under doctor's recommendation;
smokers;
arthritis or carpal tunnel which may be aggravated with handgrip exercise;
known cardiovascular disease (angina) and the following co-morbid conditions:
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| Name | Affiliation | Role |
|---|---|---|
| Neil Smart, PhD | University of New England | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UNE Exercise Physiology Lab | Armidale | New South Wales | 2351 | Australia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24582191 | Background | Carlson DJ, Dieberg G, Hess NC, Millar PJ, Smart NA. Isometric exercise training for blood pressure management: a systematic review and meta-analysis. Mayo Clin Proc. 2014 Mar;89(3):327-34. doi: 10.1016/j.mayocp.2013.10.030. |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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End of exercise protocol and 12 weeks after completion
| 12 weeks and 24 weeks |