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Premature neonates are able to discriminate phonemes and voice from 28wGA at a time the neuronal network establish contact between the environment and the cortical neurones. In the present monocentric study the investigators will analyse the response of the cortical network in premature aged between 25 and 36 wGA in response to auditory stimuli using High Resolution Electroencephalography and High Density Near Infrared Spectroscopy.
Neurodevelopmental disorders may be related to functional or structural disruption of the neuronal network organization at an early stage or later in the course of development. The disruption of the initial set-up could partially explain the prevalence of neurodevelopmental risks due to prematurity. The development period between 25 and 33 wGA corresponds to the period of very great prematurity and represents a key period of neurodevelopment in terms of structural and functional establishment of neuronal networks. One way to address the functionality of the neuronal networks is to evaluate the neural response to the exogenous stimuli and to interpret the mechanisms and the developmental status of the network in their ability to develop appropriate responses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| normal 25-36 gestational week preterm infant | Active Comparator |
| |
| 25-36 gestational week preterm infant with IVH | Experimental | 25-36 gestational week preterm infant with Intraventricular haemorrhages (IVH) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EEG | Procedure | Response of the cortical network in premature aged between 25 and 36 wGA in response to auditory stimuli using High Resolution Electroencephalography will be performed |
| Measure | Description | Time Frame |
|---|---|---|
| measure at which age the ability to discriminate time features occurs in premature neonates with Matlab Friedtrip toolbox | measure at which age the ability to discriminate time features occurs in premature neonates. For the analysis of discrimination, the investigators will use cluster analysis as implemented in the Matlab Friedtrip toolbox. | at day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| variation of the ability to discriminate time features between the IVH and normal preterm groups with BESA statistical tools | variation of the ability to discriminate time features between the IVH and normal preterm groups. For the analysis of time-frequency responses, the investigators will use cluster randomization procedures as implemented in the BESA statistical tools. | at day 0 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fabrice Wallois, Pr | Contact | (33)322087775 | fabrice.wallois@u-picardie.fr |
| Name | Affiliation | Role |
|---|---|---|
| Ghilda Ghostine, MD | CHU Amiens | Principal Investigator |
| Guy Kongolo, MD | CHU Amiens | Principal Investigator |
| Sabrina Goudjil, MD |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Amiens | Recruiting | Amiens | 80054 | France |
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| NIRS | Procedure | Response of the cortical network in premature aged between 25 and 36 wGA in response to auditory stimuli using High Density Near Infrared Spectroscopy will be performed |
|
| CHU Amiens |
| Principal Investigator |
| André Léké, MD | CHU Amiens | Principal Investigator |
| Christèle Chazal, MD | CHU Amiens | Principal Investigator |
| Pierre Tourneux, Pr | CHU Amiens | Principal Investigator |
| Coralie Degorre, MD | CHU Amiens | Principal Investigator |
| Emilie Bourel, MD | CHU Amiens | Principal Investigator |
| Laura Routier, MD | CHU Amiens | Principal Investigator |
| Claire Héberlé, MD | CHU Amiens | Principal Investigator |