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| ID | Type | Description | Link |
|---|---|---|---|
| 2021-A02615-36 | Registry Identifier | ID-RCB |
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Children born prematurely may present a neurodevelopmental disorder with a language delay diagnosed as early as 2-3 years of age. This situation is not uncommon: each year in France, approximately 35,000 children are born between 32 and 36 weeks of amenorrhea.
In our most recent work, we have shown that moderate premature infants show an attenuated cortical response to a vowel change, suggesting a deficit in the cortical encoding of vowels. This work needs to be continued in order to better understand syllable encoding and identify the neuroplasticity mechanisms underlying early speech encoding.
The identification of markers to predict language development is essential for the screening of these children at risk of language delay. These children could thus benefit from early adapted care even before the appearance of language deficits.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Longitudinal follow-up | Other | Follow-up of children at 40 weeks of corrected age for all children and then regularly until 24 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Electroencephalography | Other | experimental task, neuropsychological evaluation, clinical exam |
|
| Measure | Description | Time Frame |
|---|---|---|
| Study the impact of moderate prematurity on speech encoding characteristics development | Latency and amplitude of cortical and subcortical auditory evoked potentials in response to syllables, measured by Electroencephalography | 40 amenorrhea weeks |
| Study the impact of moderate prematurity on speech encoding characteristics development | Latency and amplitude of cortical and subcortical auditory evoked potentials in response to syllables, measured by Electroencephalography | 3 months |
| Study the impact of moderate prematurity on speech encoding characteristics development | Latency and amplitude of cortical and subcortical auditory evoked potentials in response to syllables, measured by Electroencephalography | 6 months |
| Study the impact of moderate prematurity on speech encoding characteristics development | Latency and amplitude of cortical and subcortical auditory evoked potentials in response to syllables, measured by Electroencephalography | 10 months |
| Study the impact of moderate prematurity on speech encoding characteristics development | Latency and amplitude of cortical and subcortical auditory evoked potentials in response to syllables , measured by Electroencephalography | 18 months |
| Study the impact of moderate prematurity on speech encoding characteristics development | Latency and amplitude of cortical and subcortical auditory evoked potentials in response to syllables , measured by Electroencephalography |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Beatrice Desnous, MD | Contact | 04 91 38 73 67 | 33 | beatrice.desnous@ap-hm.fr |
| Name | Affiliation | Role |
|---|---|---|
| Francois Cremieux | AP-HM | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de Neuropédiatrie | Recruiting | Marseille | 13005 | France |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| 24 months |
| D000091642 | Urogenital Diseases |