Enamel Matrix Derivatives & Periodontal Therapy in Diabetic Patients

The Impact of Enamel Matrix Derivatives on Periodontal Healing in Diabetic Patients After Non-Surgical Periodontal Therapy

The aim of this study is to compare periodontal treatment with or without the adjunct of an enamel matrix derivative in terms of periodontal healing in diabetic patients.

Patients with periodontitis will be randomly allocated to two groups. In both groups, periodontal root instrumentation will be performed. In the test group, an additional flapless application of enamel matrix derivatives will be granted for sites with pockets deeper than 5 mm.

Metabolic glucose control as measured through blood testing and local parameters of periodontal health will be measured at baseline and three months after treatment completion.

Inclusion Criteria:

• Patients diagnosed with diabetes mellitus type II and currently under treatment;
• No previous periodontal treatment in the last 6 months;
• Presence of Periodontitis (Clinical attachment loss of at least 3 mm in 2 or more non- adjacent teeth);
• Ability to understand the study procedures and comply with them through the length of the study.

Exclusion Criteria:

• Pregnancy and breast feeding;
• Need for antibiotic treatment during periodontal therapy;
• Chronic infections;
• Systemic diseases;
• Patients who report current smoking over 20 cigarettes per day.