Amelogenins and Systemic Inflammation After Periodontal Surgical Therapy

Enamel Matrix Derivatives on Systemic Inflammation After Periodontal Surgical Therapy

The aim of this study is to compare surgical treatment of periodontal infrabony defects with and without the adjunct of an enemal matrix derivative (EMD) in terms of acute-phase responses, in systemic healthy patients.

Inclusion Criteria:

• Good health
• No previous periodontal surgical treatment
• Indication for periodontal surgery (intrabony defects to be at least 4 mm deep)
• Ability to understand the study procedures and comply with them through the length of the study

Exclusion Criteria:

• Pregnancy, breast feeding or taking oral contraceptive (all non-drug contraceptives will be allowed)
• The need for antibiotic therapy to undergo periodontal therapy
• Chronic infections
• Systemic diseases
• Patients who report current smoking over 20 cigarettes per day or pipe or cigar