Source-monitoring & Psychosis

Source-monitoring Processes and Risk for Psychosis

Source-monitoring is a cognitive process that refers to the ability to remember the source of an information. Some studies have showed source-monitoring deficits in patients with schizophrenia as well as in individuals at ultra-high risk for psychosis (UHR) and in first-episode psychosis patients (FEP). Source-monitoring deficits have thus been proposed as a potential early risk factor for psychosis. However, further studies are needed to better characterize this deficit.

The aim of this project is to investigate source-monitoring performances in UHR, FEP patients and healthy controls (HC) and to characterize these deficits in terms of brain anatomy, basic auditory processes and social functioning.

Ninety participants will be included in the study: 30 UHR, 30 FEP and 30 healthy controls. All the participants will complete a standardized source-monitoring task, an MRI acquisition (3D-T1 anatomical scan), a tone-matching task as well as a socio-demographic and clinical evaluation including an assessment of the social functioning.

Inclusion Criteria:

• Men and Women aged between 18 and 30
• Having given their written informed consent
• French speakers and readers
• Absence of hearing impairments (or tinnitus) that could prevent the successful completion of tasks involving listening to sounds or words
• Absence of visual impairments that could prevent the successful completion of tasks involving reading on the screen
• For the healthy control group, no history of previous diagnosed psychiatric disorders (according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders - DSM5), absence of relatives diagnosed with spectrum disorder schizophrenia and bipolar disorder (DSM5), absence of psychotic prodromes measured by a score of less than 6 in the "prodromal questionnaire" - PQ-16 (Ising et al., 2012), absence of drug treatments (except oral contraception).
• For the UHR group, meeting the UHR criteria according to the "Comprehensive Assessment of at-risk mental state" (CAARMS).
• For the FEP group, presenting with daily psychotic symptoms for at least a week.

Exclusion Criteria:

• Do not consent to be included in the study
• Contraindication to MRI scan
• History of neurological disease
• Pregnancy
• Being under tutorship or curatorship
• Having developed musical abilities (that is, regularly practicing a musical instrument)