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Source-monitoring is a cognitive process that refers to the ability to remember the source of an information. Some studies have showed source-monitoring deficits in patients with schizophrenia as well as in individuals at ultra-high risk for psychosis (UHR) and in first-episode psychosis patients (FEP). Source-monitoring deficits have thus been proposed as a potential early risk factor for psychosis. However, further studies are needed to better characterize this deficit.
The aim of this project is to investigate source-monitoring performances in UHR, FEP patients and healthy controls (HC) and to characterize these deficits in terms of brain anatomy, basic auditory processes and social functioning.
Ninety participants will be included in the study: 30 UHR, 30 FEP and 30 healthy controls. All the participants will complete a standardized source-monitoring task, an MRI acquisition (3D-T1 anatomical scan), a tone-matching task as well as a socio-demographic and clinical evaluation including an assessment of the social functioning.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| individuals at ultra-high risk for psychosis (UHR) | Experimental | 30 individuals meeting the UHR criteria according to the "Comprehensive Assessment of at-risk mental state" (CAARMS) will be recruited and will complete cognitive task and MRI scan |
|
| patients with first episode psychosis (FEP) | Experimental | 30 patients with first episode psychosis (FEP) will be recruited and will complete cognitive task and MRI scan |
|
| healthy controls | Sham Comparator | 30 healthy individuals will be recruited and will complete cognitive task and MRI scan |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive tests and neuroimaging | Other | comparison of cognitive performances and brain anatomy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Source-monitoring performances | Scores obtained at a source-monitoring task (Brunelin et al., 2006) | one day |
| Measure | Description | Time Frame |
|---|---|---|
| Confidence in source-monitoring judgements | Confidence in source-monitoring judgements will be measured using a visual analogue scale (0-100) | one day |
| Grey matter volume | Grey matter volume will be assessed with a structural MRI scan (3D-T1) followed by morphometry analyses. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lydie sartelet | Contact | 0437915531 | +33 | lydie.sartelet@ch-le-vinatier.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier le Vinatier | Not yet recruiting | Bron | 69678 | France |
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| ID | Term |
|---|---|
| D011618 | Psychotic Disorders |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D009483 | Neuropsychological Tests |
| D059906 | Neuroimaging |
| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
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Three groups of participants will be recruited: individuals at ultra-high risk for psychosis, first-episode psychosis patients and healthy controls.
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| one day |
| Brain gyrification | Brain gyrification will be assessed with a structural MRI scan (3D-T1) followed by gyrification analyses. | one day |
| Basic auditory performances | scores at the Tone Matching Task (Strous et al., 1995) | one day |
| Working memory performances | scores at a working memory task (Barrouillet et al., 2004) | one day |
| Social functioning | score at the "personal and social performance scale" (0-100) | one day |
| Centre Hospitalier le Vinatier | Recruiting | Bron | 69678 | France |
|
| D003933 | Diagnosis |
| D003943 | Diagnostic Techniques, Neurological |
| D008919 | Investigative Techniques |