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the investigators will measure source-monitoring ability in patients with several neuropsychiatric condition and in healthy controls appaired in age, sex and educational level. Source-monitoring will be measured thanks to internal- and reality-monitoring informatic tasks.The investigators hypothesized patients with fronto-temporal abnormalities would show more marked deficits than patients with only frontal abnormalities.
Source-monitoring abilities will be measured thanks to reality-monitoring testing (i.e. the ability to distinguish internal-generated events from external ones) and internal-monitoring testing (i.e. the ability to distinguish an imagined source from a performed one). A source-monitoring deficit have been demonstrated in patients with psychiatric conditions such as schizophrenia and seems linked to frontotemporal abnormalities (frontotemporal dysconnectivity and temporal hypoactivity). With a total of 150 patients, the investigators will include 30 patients per group: patients with pre-dementia stage Alzheimer, Alzheimer, Fronto-Temporal dementia, Lewy Body dementia or Parkinson and Bipolar Disorder, with the hypothesis that Bipolar Disorder patients will present less marked deficit. The investigators will recruit 150 healthy controls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with with neuropsychiatric conditions | Experimental | In this arm, five groups :
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| Healthy subjects | Active Comparator | Healthy controls appaired in age, sex and educational level |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Monitoring source test | Other | Internal- and external-monitoring correct responses and inversions |
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| Measure | Description | Time Frame |
|---|---|---|
| measure source memory performance | in patients with neuropsychiatric disorders with or without temporal involvement (pre-dementia Alzheimer's disease, Alzheimer's disease - AD, fronto-temporal dementia - DFT, Lewy body dementia - DCL and bipolar disorder - TBP) and healthy volunteers matched in age, gender, and level of education. | one year |
| Measure | Description | Time Frame |
|---|---|---|
| measure the recognition of distractors | words not presented during the source monitoring test phase but presented during the recall phase. This measure will allow us to avoid that a disturbance invading the working memory or attentional capacities does not compromise the good realization of the task. | one year |
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Inclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| JEROME BRUNELIN, PHD | Contact | 00334 37 91 55 65 | jerome.brunelin@ch-le-vinatier.fr | |
| Jean-Michel DOREY, PHD | Contact | 00334 37 91 52 49 | jean-michel.dorey@ch-le-vinatier.fr |
| Name | Affiliation | Role |
|---|---|---|
| JEROME BRUNELIN, PHD | Centre Hospitalier Le Vinatier - CRNL - INSERM | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Le Vinatier | Recruiting | Bron | Auvergne-Rhône-Alpes | 69678 | France |
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| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D001714 | Bipolar Disorder |
| ID | Term |
|---|---|
| D000068105 | Bipolar and Related Disorders |
| D019964 | Mood Disorders |
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2 arms
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