PTP1B Implication in the Vascular Dysfunction Associated With Obstructive Sleep Apnea

PTP1B Implication in the Vascular Dysfunction Associated With Obstructive Sleep Apnea

Obstructive sleep apnea (OSA) syndrome is associated with increased vascular dysfunction and atherosclerosis. Especially, it has been shown that OSA associated intermittent hypoxia represents a pro inflammatory stimulus resulting in macrophage polarization.

Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signaling pathways involved in atherosclerosis. It has been shown that myeloid PTP1B deficiency protects against atherosclerosis.

As hypoxia has also been shown to increase PTP1B expression and activity, this study will evaluate the myeloid PTP1B expression and activity in patients with OSA as compared to controls and will investigate myeloid PTP1B involvement in the vascular pro inflammatory precess described in OSA.

Inclusion Criteria:

• Overnight polysomnographic recording for suspected OSA
• Apnea hypopnea index ≥ 15 per hour for OSA patients
• Apnea hypopnea index < 15 per hour for non OSA patients

Exclusion Criteria:

• past history of cardiovascular diseases
• diabetes
• dyslipidemia
• hypertension
• obesity (body mass index > 35 kg/m2
• past history or ongoing inflammatory diseases
• cognition impairment