Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome

Inflammation and Oxidative Stress of Adipose Tissue in Obese and Non-obese Patients Having Sleep Apnea Syndrome

The main objective of this study is to evaluate the decrease of inflammation of adipose tissue in obese and non-obese patients having a sleep apnea syndrome and treated or not by continuous positive airway pressure (cPAP).

An interim analysis will be performed when 40 patients will be included.

Inflammation of adipose tissue will be evaluated by RT-PCR on mRNA of pro and anti-inflammatory cytokines (IL-1, IL-6, IL-4, IL-10, IL-12, RANTES, TNFa, leptin, adiponectin, CD68).

Inclusion Criteria:

• Male between 18 and 70 years old
• Apnea Hypopnea Index > 30/h and > 5% TST with SaO2 < 90%
• patients obese (BMI > 33kg/m2) or non obese (BMI < 27kg/m2)

Exclusion Criteria:

• Female
• coronary ischemic disease, past history of CVA
• chronic pulmonary disease measured by arterial gasometry (PaO2 < 60mmHg and/or PaCO2 > 45mmHg)
• known hepatic disease
• alcohol consumption > 3 units/day
• sleepiness considered to be dangerous by the investigator
• patient having an hazardous work regarding to awareness
• patient being under anticoagulant, antiplatelet drug or having an active stent or bleeding disorder
• patient having an inflammatory syndrome (C-reactive Protein > 10)
• any allergy to local anaesthetics
• chronic muscle pain
• contraindication to MRI