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Diffusion tensor imaging (DTI) is a non-invasive MRI technique offering a functional approach that provides morphological information about the microstructures of the nerve roots. DTI is a widely used neuroimaging technique and is a current topic of research in the field of peripheral nerve imaging. The aim of this work is therefore to improve DTI sequences by specifically evaluating the contribution of the multiband technique in healthy volunteers.
For every healthy volunteer will be acquired:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Experimental | Healthy volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Optimisation of DTI sequences | Diagnostic Test | Optimisation of DTI sequences in the study of lumbar roots by MRI |
|
| Measure | Description | Time Frame |
|---|---|---|
| Image quality measured as signal-to-noise ratio and contrast-to-noise ratio | Comparison of the image quality between DTI optimized and DTI of reference. The signal-to-noise ratio is a measure that compares the level of a desired signal to the level of background noise. Mathematically, the signal-to-noise ratio is the quotient of the (mean) signal intensity measured in a region of interest and the standard deviation of the signal intensity in a region outside the anatomy of the object being imaged. The contrast-to-noise ratio is a measure of image quality based on a contrast rather than the raw signal. | Day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Fraction of anisotropy and apparent diffusion coefficient | Comparison of fraction of anisotropy, and apparent diffusion coefficient between DTI optimized and DTI of reference. The measurement of fraction of anisotropy, and apparent diffusion coefficient provides robust values for quantifying the degree of microstructural abnormalities of nerves. | Day 0 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jean-François BUDZIK, MD | GHICL | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Lille Catholic Hospitals | Lomme | 59462 | France |
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| Concordance of observed agreement measured by Cohen's kappa coefficient | Evaluation of interobserver accordance for multiband acquisitions (optimized DTI) | Day 0 |
| Concordance of observed agreement measured by Intra-class correlation coefficient | Evaluation of interobserver accordance for multiband acquisitions (optimized DTI) | Day 0 |