KDIGO Bundle to Prevent AKI in Sepsis

Prevention of Acute Renal Injury in the Septic Patient by Implementing the KDIGO Guideline in High-risk Patients Identified by Biomarkers

Summary: Controlled, prospective, randomized and randomized clinical trial of two intervention groups (standard care vs. preventive recommendations the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for AKI) of patients diagnosed with sepsis and abdominal post-surgical septic shock with positive results in the risk determination of acute renal injury by NephroCheck® Test that integrates the urinary biomarkers TIMP-2 and IGFBP-7.

Hypothesis: The implementation of a package of preventive measures proposed by the KDIGO guide can reduce the occurrence and severity of acute renal injury in the high-risk abdominal post-surgical septic patient detected by urinary biomarkers for early detection.

Inclusion Criteria:

• Patients older than 18 years.
• Patients (or their informed family members) who accept and sign the informed consent.
• Patients diagnosed with sepsis or abdominal post-surgical septic shock.

Exclusion Criteria:

• Patients under 18 years.
• Patients (or their authorized relatives) who refuse to sign the informed consent.
• Patients diagnosed with sepsis or non-surgical septic shock.
• Patients diagnosed with sepsis or septic shock of origin other than abdominal.
• Patients with AKI stages KDIGO 2 and 3 and / or renal replacement therapy.
• Patients with chronic renal failure and glomerular filtration <30 ml / min and / or undergoing treatment with dialysis or previous renal transplantation.
• Patients with AKI of origin other than the diagnosed septic, such as glomerulonephritis or interstitial nephritis, renal artery occlusion and / or postrenal obstruction.