Propolis Extract, Nanovitamin C and Nanovitamin E in Peri-implant Mucositis

Effect of Propolis Extract, Nanovitamin C and Nanovitamin E in Clinical and Microbiological Parameters of Peri-implant Mucositis: A Double-blind, Randomized, Clinical Trial

The objective of this study was to perform the first clinical trial to evaluate the effectiveness of propolis extract, nanovitamin C and nanovitamin E gel as adjuvant to mechanical debridement in clinical and microbiological parameters of implants with peri-implant mucositis

Inclusion Criteria:

• cooperative adult patients,
• with one or more implants with peri-implant mucositis, and
• presenting at least 18 months of functional loading.

Exclusion Criteria:

• refuse to participate in the study,
• patients who had implants with peri-implantitis (BOP and/or suppuration together with progressive radiographic marginal bone loss),
• patients with uncontrolled periodontitis (presence of nine or more sites with PD ≥ 5 mm and with full-mouth bleeding score (FMBS) > 25%),
• systemic diseases or conditions that could alter the results of the study (diabetes mellitus, immunosuppression, infectious diseases, rheumatoid disease, history of bisphosphonate treatment, radiotherapy, chemotherapy, etc.),
• patients who had taken local and/or systemic antibiotics less than 2 months ago,
• pregnant or breastfeeding women, and
• patients with history of allergies to the test and/or placebo components administered.