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The objective of this study is to evaluate, through clinical, microbiological and immunological tests, the changes during the experimental gingivitis and mucositis model, between teeth and implants, and between patients with a history of aggressive periodontitis and healthy individuals.
The objective of this study is to evaluate, through clinical, microbiological and immunological tests, the changes during the experimental gingivitis and mucositis model, between teeth and implants, and between patients with a history of aggressive periodontitis and healthy individuals. 20 patients will be include, 10 healthy and 10 with a history of aggressive periodontitis. All patients must present the same type of implant and abutments, with prostheses in function for more than 6 months. They should also have a tooth located in the contralateral hemi-arch in a similar position, allowing a comparison with the implant. They will be submitted to the plaque-induced inflammation by suspension of oral hygiene only in the tested areas (tooth / implant), protected by a personalized stent made of plastic, according to the experimental gingivitis and mucositis model of 21 days of duration.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimentally induced plaque | Placebo Comparator | Induced inflammation by suspension of oral hygiene |
|
| Experimentally induced plaque GAP | Experimental | Induced inflammation by suspension of oral hygiene in patients with history of Generalized Aggressive periodontitis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Experimentally induced plaque | Behavioral | Experimentally induced plaque by suspension of oral hygiene only in the tested areas (tooth / implant), protected by a personalized stent made of plastic, according to the experimental gingivitis and mucositis model of 21 days of duration |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of Modified Gingival Index in five different periods | According to the method of Löe & Silness (1963) without the bleeding in the component of prueba.Measure at each visit 0 - absence of inflammation;
| Baseline, 7 days, 14 days, 21 days, 42 days |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of Angulated Bleeding Index in five different periods | 0 - No bleeding.
| Baseline, 7 days, 14 days, 21 days, 42 days |
| Changes of Plaque Index in five different periods |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of Gingival fluid in five different periods | Gingival fluid is collected from the fluid site and the paper strip is transfer to a Periotron 6000® (Pro Flow™, Amityville, NY, USA) for assessment of the fluid volume. | Baseline, 7 days, 14 days, 21 days, 42 days |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Tamires P Dutra, G | School of Odontology of Piracicaba - Unicamp | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Piracicaba Dental School, State University of Campinas | Piracicaba | São Paulo | 13414-903 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37941050 | Derived | Dutra TP, Freitas Monteiro M, Franca-Grohmann IL, Casarin RCV, Casati MZ, Silverio Ruiz KG, Kumar PS, Sallum EA. Clinical, immunological and microbiological evaluation of experimental peri-implant mucositis and gingivitis in subjects with Grade C, stage III/IV periodontitis background. J Clin Periodontol. 2024 Feb;51(2):209-221. doi: 10.1111/jcpe.13896. Epub 2023 Nov 8. |
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| ID | Term |
|---|---|
| D005891 | Gingivitis |
| D052016 | Mucositis |
| D010520 | Aggressive Periodontitis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
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|
0 - Absence of plaque
| Baseline, 7 days, 14 days, 21 days, 42 days |
| D009057 |
| Stomatognathic Diseases |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D010518 | Periodontitis |