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| Name | Class |
|---|---|
| Research Council of Lithuania | OTHER |
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This study evaluates differences in the ocular microcirculation between septic patients and healthy subjects and the course of ocular microvasculature in survivors and non-survivors over a 24 hours period of time in septic patients
Conjunctival imaging, using IDF video microscope, and retinal imaging, using portable digital fundus camera, as well as systemic hemodynamic measurements, were performed in septic patients at three time points: at baseline, 6 hours and 24 hours. Baseline conjunctival and retinal microcirculatory parameters were compared with healthy controls.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Incident dark field videomicroscope from Braedius | Device | It allows to look at conjunctival microcirculation | ||
| Fundus camera from Optomed | Device | It allows to monitor retinal microvasculature |
| Measure | Description | Time Frame |
|---|---|---|
| Microvascular flow index in conjunctival small vessels | Differences in MFI in conjunctival small vessels between septic patients and healthy controls and differences between survivors and non-survivors | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Central retinal arteriolar equivalent of retinal vessels | Differences in central retinal arteriolar equivalent of retinal vessels between septic patients and healthy controls and differences between survivors and non-survivors | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients with sepsis or septic shock within the first 24 hours after ICU admission
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| Name | Affiliation | Role |
|---|---|---|
| Andrius o Pranskunas | Lithuanian University of Health Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital of Lithuanian university of health sciences | Kaunas | LT-50161 | Lithuania |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32266602 | Derived | Simkiene J, Pranskuniene Z, Vitkauskiene A, Pilvinis V, Boerma EC, Pranskunas A. Ocular microvascular changes in patients with sepsis: a prospective observational study. Ann Intensive Care. 2020 Apr 7;10(1):38. doi: 10.1186/s13613-020-00655-x. |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| D003229 | Conjunctival Diseases |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D005128 | Eye Diseases |