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The purpose of this study is to analyze the changes in cerebral oxygen saturation during the use of three vasopressors, phenylephrine, norepinephrine, and vasopressin, which are currently used during coronary artery bypass grafting.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Phenylephrine | Experimental |
| |
| Norepinephrine | Experimental |
| |
| Vasopressin | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phenylephrine | Drug | Continuous infusion of Phenylenphrine 250 μg/mL (=Phenylephrine 10mg * 5@ + D5W 200 mL) if mean BP < 60mmHg.
|
| Measure | Description | Time Frame |
|---|---|---|
| Cerebral oxygen saturation (%) | continuous monitoring of cerebral oxygen saturation during surgery | during surgery |
| Measure | Description | Time Frame |
|---|---|---|
| blood pressure | systolic/diastolic/mean blood pressure(mmHg) | during surgery |
| heart rate | heart rate(/min) | during surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology and Pain Medicine, Seoul National University Hospital | Seoul | 03080 | South Korea |
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| ID | Term |
|---|---|
| D010656 | Phenylephrine |
| D009638 | Norepinephrine |
| D014667 | Vasopressins |
| ID | Term |
|---|---|
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
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|
| Norepinephrine | Drug | Continuous infusion of Norepienphrine 20 μg/mL (=NE 4mg * 1@ + D5W 200 mL) if mean BP < 60mmHg.
|
|
| Vasopressin | Drug | Continuous infusion of Vasopressin 0.1 u/mL (=Vasopressin 20u * 1@ + D5W 200 mL) if mean BP < 60mmHg.
|
|
| cardiac index | cardiac index (L/min) | during surgery |
| Total amount of infused drug | Propofol, remifentanil, vasoacitve drugs | during surgery |
| Input/output | Urine output, blood loss, amount of fluid and transfusion | during surgery |
| Sublingual microscopy | using SDF imaging device | 1) After induction, 2) lateral wall or posterior wall anastomosis (if possible) 3) skin closure |
| Vascular occlusion test | using InspectraTM StO2 | 1) After induction, 2) lateral wall or posterior wall anastomosis (if possible) 3) skin closure |
| Troponin I | Troponin I (ng/mL) | during surgery, at ICU admission, 24 hours / 48 hours after ICU admission |
| lactate | lactate (mmol/L) | during surgery, at ICU admission, 24 hours / 48 hours after ICU admission |
| creatinine | creatinine (mg/dL) | during surgery, at ICU admission, 24 hours / 48 hours after ICU admission |
| albumin | albumin (g/dL) | during surgery, at ICU admission, 24 hours / 48 hours after ICU admission |
| NGAL | NGAL (ng/mL) | during surgery, at ICU admission, 24 hours / 48 hours after ICU admission |
| MACCE | Major adverse cardiac and cerebrovascular events | until 1 year after surgery |
| AKI/RRT | renal complication | until 1 year after surgery |
| D000588 |
| Amines |
| D015306 | Biogenic Monoamines |
| D001679 | Biogenic Amines |
| D002395 | Catecholamines |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D010909 | Pituitary Hormones, Posterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D009479 | Neuropeptides |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D009842 | Oligopeptides |
| D009419 | Nerve Tissue Proteins |
| D011506 | Proteins |