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Although non-invasive positive pressure ventilation (NPPV) shows the good curative effect of treating the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), some patients do not tolerate NPPV or do not benefit from it. High-flow nasal cannula (HFNC) is well tolerated and may be used to patients with AECOPD who are intolerant to NPPV treatment. This study is to evaluate the physiological effect of HFNC and compare it with NPPV.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HFNC group | Experimental | AECOPD patients receive ventilation support via HFNC. |
|
| NPPV group | Active Comparator | AECOPD patients receive ventilation support via NPPV. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HFNC | Device | HFNC provides warmed and humidified gas administered through slightly enlarged nasal prongs. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Neural respiratory drive | Neural respiratory drive is calculated by diaphragm electromyogram | 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Work of breathing | Work of breathing is calculated by the transdiaphragmatic pressure | 30 minutes |
| Transcutaneous CO2 | Transcutaneous CO2 is a non-invasive method estimated the partial pressure of arterial blood CO2. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lili Guan, PhD | Contact | +8613422288665 | dr_nickguan@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Rongchang Chen, MD | The First Affiliated Hospital of Guangzhou Medical University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The First Affiliated Hospital of Guangzhou Medical University. | Recruiting | Guangzhou | Guangdong | 510120 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41788481 | Derived | Guan L, Xu J, He Z, Zha S, Huang Q, Niu J, Zhou L, Chen R. Efficiency of neural respiratory drive changes during non-invasive ventilation and high-flow nasal cannula oxygen therapy in AECOPD patients with acute hypercapnic respiratory failure: A randomised cross-over study. Ann Intensive Care. 2026 Jan 16;16:100019. doi: 10.1016/j.aicoj.2025.100019. eCollection 2026. |
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| NPPV | Device | NPPV is the standard therapy for ventilatory failure in AECOPD. |
|
| 30 minutes |