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| Name | Class |
|---|---|
| Gilead Sciences | INDUSTRY |
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The aim of CELINE is to retrieve and re-evaluate lost to follow-up chronic hepatitis C patients in the Netherlands.
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| Measure | Description | Time Frame |
|---|---|---|
| Number of lost to follow-up (LTFU) patients successfully re-linked to care | End of study, on average 2.5 years after initiation |
| Measure | Description | Time Frame |
|---|---|---|
| Total number of LTFU patients in the investigated time period | 15 years prior to study initiation | |
| Case ascertainment rate | Established contact (via telephone or in writing) with a patient who is eligible for retrieval |
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Inclusion Criteria:
Exclusion Criteria:
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Lost to follow-up (possibly) chronically HCV-infected patients
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marleen van Dijk, MD | Contact | 0034243613999 | marleen.vandijk@radboudumc.nl |
| Name | Affiliation | Role |
|---|---|---|
| Joost Drenth, MD, PhD | Radboud University Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Radboudumc | Recruiting | Nijmegen | Gelderland | 6500 HB | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32377367 | Derived | Isfordink CJ, Brakenhoff SM, van Dijk M, van der Valk M, de Knegt RJ, Arends JE, Drenth JP; HepNed study group. Hepatitis C elimination in the Netherlands (CELINE): study protocol for nationwide retrieval of lost to follow-up patients with chronic hepatitis C. BMJ Open Gastroenterol. 2020 Apr 12;7(1):e000396. doi: 10.1136/bmjgast-2020-000396. eCollection 2020. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Apr 11, 2024 | |
| Reset | Sep 20, 2024 | |
| Release | Oct 1, 2024 | |
| Reset | Nov 22, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Apr 11, 2024 | Sep 20, 2024 | |||
| Oct 1, 2024 |
| ID | Term |
|---|---|
| D019698 | Hepatitis C, Chronic |
| ID | Term |
|---|---|
| D006526 | Hepatitis C |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
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| End of study, on average 2.5 years after initiation |
| Awareness of HCV diagnosis among LTFU patients | Number of patients who were aware of their HCV diagnosis when they are invited for re-evaluation | End of study, on average 2.5 years after initiation |
| Number of patients who never had an outpatient appointment with a hepatologist or infectious disease specialist after initial positive HCV test | End of study, on average 2.5 years after initiation |
| Number of viraemic patients at time of re-evaluation | End of study, on average 2.5 years after initiation |
| Liver fibrosis stage of retrieved patients | End of study, on average 2.5 years after initiation |
| Reasons for becoming LTFU | End of study, on average 2.5 years after initiation |
| Time of being LTFU | Defined as years since last (HCV-)related hospital visit | End of study, on average 2.5 years after initiation |
| Mode of HCV transmission | End of study, on average 2.5 years after initiation |
| Sustained virological response | Defined as the absence of HCV RNA at least 12 weeks after treatment | End of study, on average 2.5 years after initiation |
| Nov 22, 2024 |
| D006525 |
| Hepatitis, Viral, Human |
| D014777 | Virus Diseases |
| D018178 | Flaviviridae Infections |
| D012327 | RNA Virus Infections |
| D006521 | Hepatitis, Chronic |
| D006505 | Hepatitis |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |