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The aim of this observational multicenter cohort study is to gain a deeper understanding regarding the effects of treatment adaption based on information from outcome prediction models, risk stratification, as well as treatment monitoring, detection, prevention, and management of complications on course and outcome of adult patients with status epilepticus (SE).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SE patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| collection of patient data | Other | Extract data from the digital medical records, the electroencephalographic and microbiologic database. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Demographics | age, sex | between 01.01.2005 and 31.12.2023 |
| Data from acute prehospital management by the emergency medical services (EMS) | extracted from the treatment protocols of the EMS | between 01.01.2005 and 31.12.2023 |
| Duration of ICU (intensive care unit) and hospital stay, and destination at discharge | Duration of ICU (intensive care unit) and hospital stay, and destination at discharge | between 01.01.2005 and 31.12.2023 |
| Date(s) of seizure(s) captured by electroencephalographic (EEG) data | Date(s) of seizure(s) captured by EEG | between 01.01.2005 and 31.12.2023 |
| Seizure history and etiology | withdrawal from anti seizure drugs, structural, infectious, or autoimmune causes | between 01.01.2005 and 31.12.2023 |
| Number and Duration of SE episodes | Number and Duration (time) of SE episodes | between 01.01.2005 and 31.12.2023 |
| Types of SE | Types of SE according to the current guidelines from the International League of Epilepsy (ILAE) (i.e., nonconvulsive with coma, SE with motor symptoms, focal nonconvulsive SE without coma, and subtle SE | between 01.01.2005 and 31.12.2023 |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients (i.e., patients ≥18 years of age) with SE treated at the University Hospital Basel and the Cantonal Hospital Aarau.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Raoul Sutter, PD Dr. med | Contact | +41 61 265 25 25 | Raoul.Sutter@usb.ch | |
| Saskia Semmlack, Dr. med | Contact | +41 61 55 65575 | Saskia.Semmlack@usb.ch |
| Name | Affiliation | Role |
|---|---|---|
| Raoul Sutter, PD Dr. med | Clinic for Intensive Care Medicine, University Hospital Basel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cantonal Hospital Aarau (KSA) | Recruiting | Aarau | 5001 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38165316 | Derived | Fisch U, Junger AL, Baumann SM, Semmlack S, De Marchis GM, Ruegg SJ, Hunziker S, Marsch S, Sutter R. Association Between Dose Escalation of Anesthetics and Outcomes in Patients With Refractory Status Epilepticus. Neurology. 2024 Jan 23;102(2):e207995. doi: 10.1212/WNL.0000000000207995. Epub 2023 Dec 15. |
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| ID | Term |
|---|---|
| D012640 | Seizures |
| D013226 | Status Epilepticus |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Additional features of the seizure | length, level of consciousness at onset, previous epileptic seizures | between 01.01.2005 and 31.12.2023 |
| ICU Scoring Systems | Critical illness severity scores (e.g., acute physiology and chronic health Evaluation (APACHE II), simplified acute physiology score (SAPS II), sequential organ failure assessment (SOFA), etc.) | between 01.01.2005 and 31.12.2023 |
| Clinical neurologic monitoring scores | Clinical neurologic monitoring scores (e.g., Richmond Agitation-Sedation Scale (RASS) , Seda-tion-Agitation Scale (SAS), Glasgow Coma Score (GCS), Intensive Care Delirium Screening Checklist (ICDSC), Status Epilepticus Severity Score (STESS)) | between 01.01.2005 and 31.12.2023 |
| Laboratory parameters | C-Reactive Protein (CRP), albumin, Lactate Dehydrogenase (LDH), Creatin-Kinase (CK), procalcitonin, white blood cell levels, creatinine, liver enzymes, blood gas analyses, metabolic data | between 01.01.2005 and 31.12.2023 |
| Outcome measure | in-hospital death, survival, survival with neurofunctional alteration, Glasgow Outcome Score, return to neurofunctional premorbid baseline, readmission | between 01.01.2005 and 31.12.2023 |
| Therapeutic features | duration, dosage and number of treatment medication, number of antiseizure drugs, invasive procedures, such as intubation, mechanical, ventilation, vasopressors, installation of central lines, nutrition | between 01.01.2005 and 31.12.2023 |
| Monitoring of vital signs | blood pressure, heart rate, respiratory rate, oxygen saturation of the blood, body temperature, level of consciousness | between 01.01.2005 and 31.12.2023 |
| Clinic for Intensive Care Medicine, University Hospital Basel | Recruiting | Basel | 4031 | Switzerland |
|