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This retrospective observational cohort study is to assess and analyze clinical, electroencephalographic, laboratory, comorbidity, and treatment characteristics of Intensive care unit (ICU)-patients with epileptic seizures and to subsequently compare their characteristics with ICU-patients with status epilepticus (SE).
The aim of this retrospective observational cohort study is to get further insight into adult patients with epileptic seizures in ICUs in an academic tertiary medical care center regarding frequency, clinical and electroencephalogram (EEG) characteristics, treatment, course and outcome. This data could help understanding the epidemiology (including risk factors, influence of EEG), and to guide management and improve outcomes of affected patients.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| collection of patient data | Other | Patient data will be collected using the in-house digital patient record systems and the local digital electroencephalogram (EEG)-database |
| Measure | Description | Time Frame |
|---|---|---|
| Frequency of epileptic seizures | Frequency of all epileptic seizures in the ICU | between 01.01.2005 and 19.12.2018 |
| Measure | Description | Time Frame |
|---|---|---|
| Number of epileptic seizures captured by EEG | Number of epileptic seizures captured by EEG without overt clinical seizure presentation in the ICU | between 01.01.2005 and 19.12.2018 |
| Number of epileptic seizures diagnosed on the basis of clinical symptoms alone |
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Inclusion Criteria:
Exclusion Criteria:
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All adult patients (i.e., ≥18 years of age) admitted to the ICUs at the University Hospital Basel that suffered from one or more epileptic seizures (detected clinically and/or by EEG) during their ICU-stay
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| Name | Affiliation | Role |
|---|---|---|
| Raoul Sutter, PD Dr. med | Clinic for Intensive Care Medicine, University Hospital Basel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinic for Intensive Care Medicine, University Hospital Basel | Basel | 4031 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35235003 | Derived | Wagner AS, Semmlack S, Frei A, Ruegg S, Marsch S, Sutter R. Seizures and risks for recurrence in critically ill patients: an observational cohort study. J Neurol. 2022 Aug;269(8):4185-4194. doi: 10.1007/s00415-022-11038-6. Epub 2022 Mar 2. |
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| ID | Term |
|---|---|
| D012640 | Seizures |
| D013226 | Status Epilepticus |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Number of epileptic seizures diagnosed on the basis of clinical symptoms alone in the ICU |
| between 01.01.2005 and 19.12.2018 |
| Length of epileptic seizure (time) | Duration of epileptic seizure | between 01.01.2005 and 19.12.2018 |
| Semiological feature of epileptic seizure (i.e. seizure types) | Semiological feature of epileptic seizure (i.e. seizure types) emerging in ICU-patients | between 01.01.2005 and 19.12.2018 |