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This observational study reports meropenem and piperacillin plasma concentrations in patients treated with either antibiotic and simultaneous continuous renal replacement therapy (CRRT).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Meropenem treated patients |
| ||
| Piperacillin treated patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Plasma concentration measurements | Other | Plasma concentration measurements |
|
| Measure | Description | Time Frame |
|---|---|---|
| Plasma antibiotic concentrations at mid and end of dosing interval | We vill report the measured plasma antibiotic concentrations at the mid and end of the dosing interval. | 1 week |
| Plasma antibiotic concentrations at mid and end of dosing interval | The percentage of patients having a concentration above the highest MIC (minimal inhibitory concentration) breakpoint for pathogens considered susceptible for the antibiotic. | 1 week |
| Relationships between plasma antibiotic concentrations and CRRT dose. | We will report the correlation between measured plasma concentrations of either antibiotic and the intensity of the CRRT treatment. | 1 week |
| Influence of residual diuresis on the measured plasma antibiotic concentrations. | We will report the correlation between measured plasma concentrations of either antibiotic and residual diuresis. | 1 week |
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Inclusion Criteria:
Exclusion Criteria:
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ICU patients
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Karolinska University Hospital Solna | Stockholm | 17176 | Sweden |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| D007239 | Infections |
| D006461 | Hemolysis |
| ID | Term |
|---|---|
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Plasma