Elimination of Antibiotics During Renal Replacement Therapy and Cytosorb Adsorptive Therapy

Elimination of Antibiotics During Combined Continuous Renal Replacement Therapy and Cytosorb Adsorptive Therapy in Patients With Sepsis and Acute Kidney Injury

Cytokine adsorption using the cytosorb adsorber is currently investigated to reduce the levels of proinflammatory cytokines in patients with severe sepsis and septic shock. The adsorber is frequently used in series with continuous renal replacement therapy. Up to date, no data on the removal of antibiotic drugs during combined renal replacement therapy and cytokine adsorptive therapy is available. Therefore, we want to investigate

- whether and to what extent antibiotic drugs (piperacillin/tazobactam and imipenem/cilastatin) are removed during combined continuous renal replacement therapy and cytosorb adsorption in patients with severe sepsis and septic shock

Patients in this trial are undergoing renal replacement therapy as part of their routine care. Thus, this is an observational trial.

Inclusion Criteria:

• Intensive care patients with severe sepsis or septic shock and acute kidney injury requiring continuous renal replacement therapy and cytokine adsorption
• Age > 18 y

Exclusion Criteria:

• < 18 y
• Pregnancy
• Contraindications against citrate-anticoagulation or continuous renal replacement therapy or cytokine adsorption