Pharmacokinetics of Advantage Arrest

Pharmacokinetics of Advantage Arrest

The study aim is to characterize the kinetics of silver and fluoride after topical application of silver diamine fluoride.

The purpose of this study is to characterize basic PK parameters (Cmax, t1/2, AUC, and total urinary recovery) to contribute to evidence for the safety of Advantage Arrest, consistent with Guidance for Industry--Exposure--Response Relationships (April 2003).

Inclusion Criteria:

• 18 years or older, minimum 20 teeth, healthy, not taking prescription or OTC medications

Exclusion Criteria:

• pregnant, weighed less than 50 kg, had oral mucositis or ulcerative lesions, known sensitivity to silver or fluoride