Stopping Cavities Study: Diammine Silver Fluoride

Pragmatic Trial of Topical Diammine Silver Fluoride for Dental Caries Arrest

This study is being conducted to test whether the use of diammine silver fluoride (also called silver diamine fluoride) hardens the cavity sufficiently so that it arrests.

Phase III RCT with two arms: (1) 38% diammine silver fluoride; (2) distilled fluoride free water. Subjects are 200 preschool children in good general health with untreated tooth decay. Intervention is topical application of the study drug to the open cavity. Primary outcome is caries activity at 14-21 days.

Inclusion Criteria:

• Nyvad criteria 3
• Active carious lesion

Exclusion Criteria:

• Allergy to silver
• Stomatitis or oral ulcerative condition
• Weight less than 15 kg