Randomized controlled single blind trial for the evaluation of the treatment of the surgical wound healing process with Platelet-Rich-Fibrin compared to the gold standard (without Platelet-Rich-Fibrin) in patients undergoing knee replacement.

Inclusion Criteria:

• Males or females undergoing a total knee prosthesis.
• Willingness and ability to comply with the study procedures and visit schedules and ability to follow verbal and written instructions.
• Hb > 11 g/dl; Platelet value > 150.000 plt/mmc;
• Patients with non clinical alteration of ECG;
• Signature of informed consent;

Exclusion Criteria:

• Patients incapable of understanding and of wanting;
• Systemic disorders such as diabetes, rheumatic diseases;
• Patients with malignancy;
• Thyroid metabolic disorders ;
• Abuse of alcohol, drugs and pharmaceutical drugs
• Body mass index > 40;