Effectiveness of Treatment With Rich Platelet Fibrin (PRF) VS Gold Standard in Patients Undergoing Knee Replacement

Effectiveness of Treatment With Rich Platelet Fibrin (PRF) VS Gold Standard in the Healing Process of Surgical Wounds in Patients Undergoing Knee Replacement

Randomized controlled single blind trial for the evaluation of the treatment of the surgical wound healing process with Platelet-Rich-Fibrin compared to the gold standard (without Platelet-Rich-Fibrin) in patients undergoing knee replacement.

Inclusion Criteria:

• Males or females undergoing a total knee prosthesis.
• Willingness and ability to comply with the study procedures and visit schedules and ability to follow verbal and written instructions.
• Hb > 11 g/dl; Platelet value > 150.000 plt/mmc;
• Patients with non clinical alteration of ECG;
• Signature of informed consent;

Exclusion Criteria:

• Patients incapable of understanding and of wanting;
• Systemic disorders such as diabetes, rheumatic diseases;
• Patients with malignancy;
• Thyroid metabolic disorders ;
• Abuse of alcohol, drugs and pharmaceutical drugs
• Body mass index > 40;