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This study represents a prospective, controlled and randomized clinical trial assessing the effects of L-PRF on the healing time of the donor area and on the patient's postoperative morbidity in the 4 weeks following the Apically Positioned Flap (APF) procedure in the uncovering phase of two-stage implants.
A total of 40 patients were recruited and divided into two groups. The implant uncovering procedure in the test group was performed with APF and application of L-PRF on the donor area. Patients in the control group, on the other hand, were treated with APF alone, leaving the donor area to heal by secondary intention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| APF + L-PRF | Experimental | Application of a layer of L-PRF to protect the donor area after uncovering implant procedure using Apically Positioned Flap (APF). |
|
| APF without L-PRF | Active Comparator | The donor area is left to heal by secondary intention after APF in the implant uncovering procedure. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Application of L-PRF on the donor area | Procedure | After implant uncovering procedure with apically positioned flap, the donor area is covered with a layer of L-PRF |
|
| Measure | Description | Time Frame |
|---|---|---|
| Complete re-epithelialization of the wound of donor area (CWE) | Time needed to obtain a complete re-epithelialization of the wound of donor area | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Post-Operative Discomfort (D) | Evaluation of post-operative discomfort using Visual Analogue Scale (VAS).The scale is represented by a straight horizontal line of fixed length, generally 10 cm. Extremities are defined as extreme limits of the parameter to be measured, oriented from left (worst) to right (best). | 4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| G. D'Annunzio University | Chieti | 66100 | Italy |
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| Secondary intention healing of the donor area | Procedure | After implant uncovering procedure with apically positioned flap, the donor area is left to heal by secondary intention |
|
| Changes in Feedind Habits (CFH) |
Evaluation of changes in patients' feedind habits using Visual Analogue Scale (VAS).The scale is represented by a straight horizontal line of fixed length, generally 10 cm. Extremities are defined as extreme limits of the parameter to be measured, oriented from left (worst) to right (best). |
| 4 weeks |
| Consumption of Analgesics (AU) | Assessment of postoperative pain by the number of analgesics taken | 4 weeks |
| Alteration of Sensivity (AS) | Evaluation of alteration of sensivity on donor area | 4 weeks |