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The investigators hypothesis is that an injection into the inferior vena cava associated with a provocation maneuver should allow to increase the incidence of FOP found by transesophageal echocardiography in a population of patients undergoing lung transplantation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| superior without positive tele-expiratory pressure | Other | Diagnostic Test: Contrast injection in the superior vena cava territory + controlled ventilation without positive tele-expiratory pressure |
|
| superior with 10 cmH2O positive tele-expiratory pressure | Other | Diagnostic Test: Contrast injection in the superior vena cava territory + controlled ventilation with 10 cmH2O positive tele-expiratory pressure |
|
| inferior without positive tele-expiratory pressure | Other | Diagnostic Test: Contrast injection in the inferior vena cava territory + controlled ventilation without positive tele-expiratory pressure |
|
| inferior with 10 cmH2O positive tele-expiratory pressur | Other | Diagnostic Test: Contrast injection in the inferior vena cava territory + controlled ventilation with 10 cmH2O positive tele-expiratory pressure |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| search for a patent foramen ovale | Diagnostic Test | Injection of a contrast solution A - In the upper cellar territory with controlled ventilation without positive tele-expiratory pressure; B - In the upper cellar territory in controlled ventilation with a positive end-to-expiratory pressure of 10cm H2O; C - In the lower cellar territory with controlled ventilation without positive tele-expiratory pressure; D - In the lower cellar territory in controlled ventilation with a positive end-to-expiratory pressure of 10cm H2O; |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of transatrial passage of contrast media | Incidence of transatrial passage of contrast media | 1 day after lung transplantation |
| Measure | Description | Time Frame |
|---|---|---|
| Size of PFO, existence of an atrial septal aneurysm | 1 day after lung transplantation | |
| Number of postoperative days with mechanical ventilation | 30 days after lung transplantation | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Maxime Davignon, MD | Hopital Foch | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hopital Foch | Suresnes | 92151 | France |
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For each patient the 4 tests will be performed in a randomized order to limit bias
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| Incidence of pulmonary graft dysfunction, incidence of stroke, incidence of myocardial ischemia |
| 30 days after lung transplantation |
| Mortality during the stay in the intensive care unit | 30 days after lung transplantation |
| Mortality during the stay in the hospital | 30 days after lung transplantation |
| Mortality at the postoperative 30-day | 30 days after lung transplantation |