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This study will evaluate if an association exists between levels of blood flow through the pulmonary veins and the incidence of graft dysfunction post operatively.
Lung transplantation surgery can be fraught with a multitude of early as well as delayed complications leading to increased morbidity and mortality. During lung transplant surgery, trans-esophageal echocardiography (TEE) is routinely used to identify cardiac anatomy and measure blood flow through the pulmonary veins. This blood flow is assessed both before and after the lung has been transplanted. Blood flow through these small caliber vessels can be impacted by many variables with a resulting reduction in blood circulating to the lung, although currently there is no agreement on an acceptable level of flow. This study will look at retrospective data from lung transplant surgeries undertaken at this institution since Jan 1st 2014 until November 18th 2016 with the goal of determining if an association exists between levels of blood flow through the pulmonary veins and the incidence of graft dysfunction post operatively.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lung Transplant Surgery | Subjects included in the study will have undergone a single or bilateral lung transplant surgery at The Ohio State University Wexner Medical Center between 01 JAN 2014 and 18 NOV 2016. No investigational intervention performed for this study. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No investigational intervention performed for this study | Other | No investigational intervention for the purpose of this study was performed; data collected is retrospective data previously collected for non-research purposes. |
| Measure | Description | Time Frame |
|---|---|---|
| incidence of graft dysfunction | To describe the relationship between intra-operative pulmonary vein systolic velocities and the incidence of graft dysfunction as defined by the International Society for Heart and Lung Transplantation (ISHLT). | at 30 days post-transplant |
| grade of graft dysfunction | To describe the relationship between intra-operative pulmonary vein systolic velocities and grade of graft dysfunction as defined by the International Society for Heart and Lung Transplantation (ISHLT). | at 30 days post-transplant |
| Measure | Description | Time Frame |
|---|---|---|
| All-cause mortality | To measure and report all-cause mortality at 30 days post-transplant. | at 30 days post-transplant |
| Hospital Length of Stay | To report subjects hospital length of stay for up to one year. |
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Inclusion Criteria:
Exclusion Criteria:
1. Patients ≤ 18 years of age
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The study population will include all surgical patients 18 years of age and older who underwent single or bilateral lung transplantation surgery during the period January 1st 2014 to November 18 2016 at Ohio State University Wexner Medical Center. Database screening for patient inclusion in retrospective analysis will be performed by designated personnel from the Anesthesiology Department or co-investigators entitled to work with patients' electronic data.
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| Name | Affiliation | Role |
|---|---|---|
| Amar Bhatt, MD | Ohio State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | United States |
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| From hospital admission to discharge up to one year. |