Evaluation and Reconditioning of Marginal Lung Donors to Transplantation by ex Vivo Lung Perfusion

Evaluation and Reconditioning of Marginal Lung Donors to Transplantation by ex Vivo Lung Perfusion

Only about 15% of the potential candidates for lung donation are considered suitable for transplantation. A new method for ex vivo lung perfusion (EVLP) has been developed and can be used for evaluation and reconditioning of "marginal" and unacceptable lungs. The ´purpose of this study is to analyse the executability and safety of ex vivo lung perfusion pulmonary ex vivo in marginal donors.

Donor Inclusion criteria:

• Age < 55 years-old;
• Smoking history < 20 pack-year;
• Clear chest radiograph;
• Absence of significant chest trauma;
• Absence of purulent secretions and gastric contents at bronchoscopy;
• PaO2 < 300 mm Hg (FIO2 1.0, PEEP 5 cmH2O)

Exclusion criteria:

• Lungs presenting PO2 < 400 mmHg after ex vivo lung perfusion

Inclusion Criteria:

• Age < 55 years-old;
• Smoking history < 20 pack-year;
• Clear chest radiograph;
• Absence of significant chest trauma;
• Absence of purulent secretions and gastric contents at bronchoscopy;
• PaO2 < 300 mm Hg (FIO2 1.0, PEEP 5 cmH2O)

Exclusion Criteria:

• Lungs presenting PO2 < 400 mmHg after ex vivo lung perfusion