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The aim of this study is to compare pulmonary function, respiratory muscle strength, exercise capacity and peripheral muscle strength of patients with CF, PCD and healthy childrens.
The impaired airway clearence and pulmonary functions, exercise intolerance, low physical activity level and decreased peripheral muscle strength make physiotherapy approaches important in the management of CF and PCD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cystic fibrosis | children with cystic fibrosis |
| |
| primary ciliary dyskinesia | children with primary ciliary dyskinesia |
| |
| healthy controls | Age-matched healthy volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Measurement of functional capacity | Other | Functional capacity of participants will be measured with six-minute walk test. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Six-minute walk test distance | Distance walked in six minutes will be recorded in meters. Test will be conducted according to the guideline of American Thoracic Society (ATS). | 15 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Forced Vital Capacity (FVC) | FVC will be measured using basic spirometry and expressed as the percentage of the predicted value according to the guideline of European Respiratory Society (ERS) | 5 minutes |
| Forced Expiratory Volume in 1 second (FEV1) |
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Inclusion Criteria:
Exclusion Criteria:
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Children diagnosed with cystic fibrosis and primary ciliary dyskinesia and age matched healthy volunteers who do not have any diagnosed chronic diseases
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| Name | Affiliation | Role |
|---|---|---|
| Hilal Denizoglu Kulli, PhD | Bezmialem Vakif University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bezmialem Vakıf University | Istanbul | Turkey (Türkiye) |
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| pulmonary function test | Other | It will be measured using basic spirometry and presented lung volume parameters such as FEV1,FVC,FEV1/FVC,PEF, FEF25-75 |
|
| Functional capacity | Other | Functional capacity of participants will be measured with six-minute walk test and sit-to-stand test |
|
| Peripheral muscle strength | Other | Isometric M. Quadriceps strength will be measured using electronic hand held dynamometer in sitting position. |
|
| Respiratory muscle strength | Other | Inspiratory and expiratory muscle strength has been assessed by maximal inspiratory and expiratory mouth pressures. |
|
FEV1 will be measured using basic spirometry and expressed as the percentage of the predicted value according to the guideline of European Respiratory Society (ERS)
| 5 minutes |
| Peak Expiratory Flow (PEF) | PEF will be measured using basic spirometry and expressed as the percentage of the predicted value according to the guideline of European Respiratory Society (ERS) | 5 minutes |
| M. Quadriceps strength | Isometric M. Quadriceps strength (kg) will be measured using electronic hand held dynamometer in sitting position. | 5 minutes |
| ID | Term |
|---|---|
| D002925 | Ciliary Motility Disorders |
| D003550 | Cystic Fibrosis |
| ID | Term |
|---|---|
| D012140 | Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D000072661 | Ciliopathies |
| D000015 | Abnormalities, Multiple |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D030342 | Genetic Diseases, Inborn |
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D008171 | Lung Diseases |
| D007232 | Infant, Newborn, Diseases |
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| ID | Term |
|---|---|
| D012143 | Respiratory Physiological Phenomena |
| D005652 | Functional Residual Capacity |
| ID | Term |
|---|---|
| D002943 | Circulatory and Respiratory Physiological Phenomena |
| D014109 | Total Lung Capacity |
| D008176 | Lung Volume Measurements |
| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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