Mangoselect®: Characterization, Pharmacokinetics and Bioavailability of Xanthone Metabolites

Evaluation of Absorption and Metabolism of Phenolic Compounds From Mangoselect®, an Extract of Mangosteen. Comparison of Two Versions During a Randomized, Double-blinded and Cross-over Trial

The aim of this study is to compare pharmacokinetics and bioavailability of phenolic compounds, mainly xanthones, from a mangosteen extract, either ingested in a dry powder form or in an encapsulated form. Absorption and metabolism will be determined by measuring urinary excretion of phenolic metabolites and blood metabolic profile over 72 hours by means of High Pressure Liquid Chromatography (HPLC) coupled with tandem mass spectroscopy.

The design of this study is a cross-over, double-blind and randomized trial on 10 healthy subjects.

Inclusion Criteria:

• Provision of signed and dated informed consent study
• Stated willingness to comply with all the study procedures and availability for the duration of the study
• Male and female
• Normal BMI range (18.50-24.99)
• In good general health as evidenced by medical history
• Ability to take oral medication and be willing to adhere to lifestyle considerations

Exclusion Criteria:

• Current use of any medication or food supplement
• Pregnancy or lactation
• Known allergic reaction to mangosteen
• Metabolic disorders or any kind of disease
• Currant smoker