Effect of Mango on Gut Microbiota and Metabolic Health

Metabolic Adaptations and Role of Nutritionally-Mediated Gut Microbiota Changes Following Mango Consumption in Overweight Men and Women : The MANGO Pilot Study

Mango is rich in bioactive compounds such as dietary polyphenols and carotenoids, which may explain its beneficial effect on health. Polyphenols accumulate in the gut where they can positively modulate the microbiota. As gut microbiota may have a strong influence on cardiometabolic health, we hypothesize that mango consumption improves metabolic profile in overweight or obese individuals through beneficial changes in gut microbiota. The study of metagenomics, transcriptomics and metabolomics will be used to validate this hypothesis.

Inclusion Criteria:

• Healthy men and premenopausal women
• At least one of the following : BMI between 25 and 40 kg/m2 or Waist circumference ≥ 80 cm for women and ≥ 94 cm for men
• At least one of the following : TG ≥ 1.35 mmol/L or fasting insulinemia ≥ 42 pmol/L
• Caucasian origin

Exclusion Criteria:

• Nicotine use
• Metabolic disorders or use of medication that may affect parameters measured in the study
• Use of dietary supplements or natural health product that may affect parameters measured in the study
• Use of antibiotics in the last 3 months
• Surgery in the last 3 months or planned during the study timeline
• Alcohol consumption >2 drinks/day
• Weight change >5% in the last 3 months
• Mango aversion, allergy or intolerance
• Dietary restrictions (vegetarian, gluten avoidance...)
• Berries consumption >1 serving/day
• Pregnancy, breastfeeding or pregnancy planned within 3-6 months