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This study will investigate the effects on the SIMEOX technology on flow and volume generated in healthy subjects and patients with COPD
This is a crossover study assessing the immediate physiological effects of SIMEOX and a PEP device on the exhalation phase in healthy subjects and patients with COPD.
Participants will perform (1) a slow vital capacity, (2) a maximal expiration from total lung capacity to residual volume with SIMEOX, (3) a maximal expiration from total lung capacity to residual volume with a PEP device.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Spontaneous slow vital capacity | Active Comparator | Participants will have to perform a slow vital capacity according to the guidelines, from total lung capacity to residual volume |
|
| SIMEOX | Active Comparator | Participants will have to perform a passive exhalation using the SIMEOX, starting from total lung capacity and going until achieving residual volume |
|
| PEP | Active Comparator | Participants will have to perform an active exhalation using a PEP device, starting from total lung capacity and going until achieving residual volume |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SIMEOX | Device | SIMEOX is a device generating a succession of gentle depression at the mouth. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change in expiratory volume | Expiratory volume change between the 3 conditions (spontaneous expiration, SIMEOX and PEP). | 5 minutes |
| Change in expiratory flow | Expiratory flow change between the 3 conditions (spontaneous expiration, SIMEOX and PEP). | 5 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cliniques universitaires Saint-Luc | Brussels | Brussels Capital | 1200 | Belgium |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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| PEP |
| Device |
A PEP device (Pari-PEP) will be used to provoke a positive expiratory pressure while exhaling, thereby stabilizing the airways during expiration. |
|
| Spontaneous Exhalation | Other | A slow vital capacity maneuver will be performed according to the guidelines, from total lung capacity to residual volume |
|
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |