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| Name | Class |
|---|---|
| Bill and Melinda Gates Foundation | OTHER |
| University of Witwatersrand, South Africa | OTHER |
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To achieve global goals for the treatment of HIV, most high-prevalence countries are experimenting with and scaling up differentiated service delivery models (DSD). A handful of efforts have been formally described and evaluated in the literature; many others are being implemented formally or informally under routine care, without a research or evaluation goal. For most countries, however, we have little evidence on the big picture-the proportion of clinics offering alternative models, eligibility criteria and the proportion of patients considered eligible, the number of patients actually participating, health outcomes such as viral suppression, empirical resource utilization compared to traditional care, variations among the models, duration of patient participation, fidelity to model guidelines, effects on clinic efficiency, and sustainability without external donor support.
AMBIT a set of data synthesis, data collection, and data analysis activities aimed at generating information for near- and long-term decision making and creating an approach and platform for ongoing evaluation of differentiated models of HIV treatment delivery in the future. The project will collect and analyze a wide range of existing data sets pertinent to DSD. This protocol is for an analysis of existing medical record data collected by the Department of Health, implementing partners, and other completed, ongoing, or new evaluations, trials, and observational studies. Outcomes to be reported include coverage/uptake of DSD, patients' outcomes, and distribution of each model. There will be no study interaction with individual patients, providers, caregivers, or others for this analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients enrolled in differentiated service delivery models |
| ||
| Patients not enrolled in DSD models |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Routine medical record data collection | Other | The study will collect routine medical record data from the electronic medical record system, other electronic databases, and paper charts. |
| Measure | Description | Time Frame |
|---|---|---|
| Patient-months enrolled in any DSD model | % of all patient-months of ART provided for the cohort that are provided within DSD models | 12 months |
| Patient-months enrolled in any DSD model | % of all patient-months of ART provided for the cohort that are provided within DSD models | 24 months |
| Patient-months enrolled in any DSD model | % of all patient-months of ART provided for the cohort that are provided within DSD models | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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All adults who are accessing care for HIV anywhere in the country.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Matthew A Fox, DSc | Contact | 617 414 1270 | mfox@bu.edu | |
| Sydney B Rosen, MPA | Contact | 617 358 2251 | sbrosen@bu.edu |
| Name | Affiliation | Role |
|---|---|---|
| Sydney B Rosen, MPA | Boston University School of Public Health, Global Health | Principal Investigator |
| Matthew A Fox, DSc | Boston University School of Public Health, Global Health | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| All clinics | Recruiting | Johannesburg | 2193 | South Africa |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40857347 | Derived | Huber AN, Jamieson L, Fox MP, Manganye M, Malala L, Chidarikire T, Khoza N, Nichols BE, Rosen S, Pascoe S. Evaluating the impact of differentiated service delivery (DSD) on retention in care and HIV viral suppression in South Africa: A target trial emulation using routine healthcare data. PLoS Med. 2025 Aug 26;22(8):e1004489. doi: 10.1371/journal.pmed.1004489. eCollection 2025 Aug. |
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