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| ID | Type | Description | Link |
|---|---|---|---|
| A074000 | Other Identifier | UW Madison | |
| AG&LSC/FOOD SCIENCE/FOOD SCIEN | Other Identifier | UW Madison | |
| Protocol Version 1/10/2019 | Other Identifier | UW Madison |
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| Name | Class |
|---|---|
| National Dairy Council | OTHER |
| University of Massachusetts, Amherst | OTHER |
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The objective of this study is to conduct a randomized cross-over dietary intervention in adult women who are overweight or obese to compare how yogurt and a control food affect biomarkers of inflammation and intestinal health.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Yogurt-Control | Experimental | Consumption of 12 oz. of low-fat yogurt daily (2 x 6 oz. servings) for 4 weeks, followed by a washout phase for 4 weeks, then consumption of 12 oz. control food (flavored soy pudding, 2 x 6 oz. servings) for 4 weeks. |
|
| Control-Yogurt | Experimental | Consumption of control food (flavored soy pudding, 2 x 6 oz. servings), followed by a washout phase for 4 weeks, then consumption of 12 oz. of low-fat yogurt daily (2 x 6 oz. servings) for 4 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Yogurt | Other | Low-fat flavored yogurt |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Th17 proportion | Change in proportions of circulating Th17 cells (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Treg proportion | Change in proportion of circulating Treg cells (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in Treg subpopulation | Change in proportion of circulating Treg subpopulation (FoxP3+ IL-10+) (change in control vs. change in yogurt) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in systolic blood pressure | Change in resting systolic blood pressure (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in diastolic blood pressure | Change in resting diastolic blood pressure (change in control vs. change in yogurt) |
Inclusion Criteria:
Exclusion Criteria:
Female
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| Name | Affiliation | Role |
|---|---|---|
| Bradley W Bolling, PhD | University of Wisconsin, Madison | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Food Science, Babcock Hall | Madison | Wisconsin | 53706 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39153426 | Derived | Hasegawa Y, Noll AL, Lang DJ, Akfaly EM, Liu Z, Bolling BW. Low-fat yogurt consumption maintains biomarkers of immune function relative to nondairy control food in women with elevated BMI: A randomized controlled crossover trial. Nutr Res. 2024 Sep;129:1-13. doi: 10.1016/j.nutres.2024.07.005. Epub 2024 Jul 24. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D015014 | Yogurt |
| D064088 | Hazard Analysis and Critical Control Points |
| ID | Term |
|---|---|
| D043302 | Cultured Milk Products |
| D008892 | Milk |
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
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| Control food |
| Other |
Low-fat flavored soy pudding |
|
| Baseline, Week 4, Week 8, Week 12 |
| Change in Th17 subpopulation (IL-17A+ TNFα+) | Change in proportion of circulating Th17 subpopulation (IL-17A+ TNFα+) (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in Th17 subpopulation (IL-17A+ IFNδ+) | Change in proportion of circulating Th17 subpopulation (IL-17A+ IFNδ+) (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in Th17 subpopulation (IL-17A+ IL-22+) | Change in proportion of circulating Th17 subpopulation (IL-17A+ IL-22+) (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in Th17 subpopulation (IL-17A+ FoxP3+) | Change in proportion of circulating Th17 subpopulation (IL-17A+ FoxP3+) (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in Th17 subpopulation (IL-17A+ IL-10+) | Change in proportion of circulating Th17 subpopulation (IL-17A+ IL-10+) (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in plasma tumor necrosis factor alpha (TNF-alpha) | Change in fasting plasma TNF-alpha (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in plasma interferon gamma (IFN-gamma) | Change in fasting plasma IFN-gamma (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in plasma interleukin-6 (IL-6) | Change in fasting plasma IL-6 (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in plasma interleukin-17A (IL-17A) | Change in fasting plasma IL-17A (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in plasma interleukin-4 | Change in fasting plasma IL-4 (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in plasma interleukin-22 (IL-22) | Change in fasting plasma IL-22 (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in plasma interleukin-10 (IL-10) | Change in fasting plasma IL-10 (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in plasma transforming growth factor beta (TGF-beta) | Change in fasting plasma TGF-beta (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in retinoic acid receptor-related orphan nuclear receptor gamma T (RORgammaT) expression | Change in fasting plasma RORgammaT expression (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in Forkhead box P3 (FoxP3) expression | Change in fasting FoxP3 expression (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in fecal calprotectin | Change in fecal calprotectin (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in fecal tumor necrosis factor alpha (TNF-alpha) | Change in fecal TNF-alpha (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in fecal interleukin 1 alpha (IL-1alpha) | Change in fecal IL-1alpha (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in fecal interleukin 1beta (IL-1beta) | Change in fecal IL-1beta (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in fecal interleukin-6 (IL-6) | Change in fecal IL-6 (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in fecal interleukin-17A (IL-17A) | Change in fecal IL-17A (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Baseline, Week 4, Week 8, Week 12 |
| Change in BMI | Body mass index (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in Weight | Change in body weight (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in waist circumference | Change in waist circumference (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Compliance: Number of lids and Unused Containers | Number of lids and unused containers of intervention foods (control vs. yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Dietary records | Comparison of dietary records (control vs. yogurt) | 2 Weeks Prior to Intervention, Weeks 0-4, Weeks 4-8, Weeks 8-12 |
| Change in gut microbiota diversity | Change in gut microbiota beta diversity (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in fecal water ex vivo barrier disrupting activity | Change in barrier disrupting activity of fecal water applied to cultured Caco-2 cells (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in fecal total organic carbon | Change in total organic carbon (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in fecal butyrate | Change in fecal butyrate (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in fecal propionate | Change in fecal propionate (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in fecal acetate | Change in fecal acetate (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in fecal bile acid (deoxycholic acid) | Change in fecal deoxycholic acid (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in fecal bile acid (lithocholic acid) | Change in fecal lithocholic acid (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in fecal bile acid (hyodeoxycholic acid) | Change in fecal hyodeoxycholic acid (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| Change in fecal bile acid (3β,12α-Dihydroxy-5β-cholan-24-oic acid) | Change in fecal 3β,12α-Dihydroxy-5β-cholan-24-oic acid (change in control vs. change in yogurt) | Baseline, Week 4, Week 8, Week 12 |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010335 | Pathologic Processes |
| D010829 |
| Physiological Phenomena |
| D000074421 | Fermented Foods |
| D003611 | Dairy Products |
| D005502 | Food |
| D019602 | Food and Beverages |
| D059022 | Food Safety |
| D063427 | Food Quality |
| D005524 | Food Technology |
| D019649 | Food Industry |
| D007221 | Industry |
| D013676 | Technology, Industry, and Agriculture |
| D012449 | Safety |
| D000056 | Accident Prevention |
| D000059 | Accidents |
| D011634 | Public Health |
| D004778 | Environment and Public Health |