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In view of the current problem of treating high myopic macular schisis, the main purpose of our study is to find out the most appropriate time of surgical intervention, to compare the effectiveness and safety of various surgical methods in the treatment of high myopic macular schisis, and to find out the advantages and disadvantages of each surgical method in the treatment of MF. As well as the outcomes and complications of long-term follow-up.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | ||
| PPV+/-Cat | Active Comparator |
| |
| PPV+/-Cat+Gas | Active Comparator |
| |
| PPV+ILM+/-Cat+/-Gas | Active Comparator |
| |
| PPV+ILM+/-Cat+/-Oil | Active Comparator |
| |
| PSR | Active Comparator |
| |
| PSR+ PPV+ILM+/-Cat+/-Oil (or Gas) | Active Comparator |
| |
| Gas | Active Comparator |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PPV+/-Cat | Procedure | pars plana vitrectomy+/-cataract |
| |
| PPV+/-Cat+Gas |
| Measure | Description | Time Frame |
|---|---|---|
| foveal thickness | measured by OCT | change from baseline foveal thickness at 3, 6, 9, 12 months |
| retinal thickness of the most significant schisis | measured by OCT | change from baseline at 3, 6, 9, 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| best corrected visual acuity | BCVA | change from baseline at 3, 6, 9, 12 months |
| mf-ERG | multifocal-ERG | change from baseline at 3, 6, 9, 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jiasong Yang | Contact | +8618113024536 | cammel@qq.com | |
| Wensheng Li | Contact | +8618650424985 | drlws@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| Weisheng Li | Shanghai Aier Eye Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Aier Eye Hospital | Recruiting | Shanghai | Shanghai Municipality | 200000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31060414 | Background | Dolar-Szczasny J, Swiech-Zubilewicz A, Mackiewicz J. A Review of Current Myopic Foveoschisis Management Strategies. Semin Ophthalmol. 2019;34(3):146-156. doi: 10.1080/08820538.2019.1610180. Epub 2019 May 6. |
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|
| Procedure |
pars plana vitrectomy+/-cataract+gas tamponade |
|
| PPV+ILM+/-Cat+/-Gas | Procedure | pars plana vitrectomy+internal limiting membrane peeling+/-cataract+/-gas tamponade |
|
| PPV+ILM+/-Cat+/-Oil | Procedure | pars plana vitrectomy+internal limiting membrane peeling+/-cataract+/-silicone oil tamponade |
|
| PSR | Procedure | posterior scleral reinforcement |
|
| PSR+ PPV+ILM+/-Cat+/-Oil (or Gas) | Procedure | posterior scleral reinforcement+pars plana vitrectomy+internal limiting membrane peeling+/-cataract+/-silicone oil tamponade (or gas) |
|
| Gas | Procedure | gas tamponade alone |
|
| Visual quality questionnaire | Visual quality questionnaire | change from baseline at 3, 6, 9, 12 months |
| axial length | axial length measured by IOL Master | change from baseline at 3, 6, 9, 12 months |
| ID | Term |
|---|---|
| D005740 | Gases |
| ID | Term |
|---|---|
| D007287 | Inorganic Chemicals |
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