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Sentinel Lymph Node Biopsy (SLNB) after nipple sparing mastectomy (NSM) is controversial. This study aims to investigate feasibility of SLNB with radioisotope method.
Volunteer patients who has underwent to NSM at least more than 6 months prior will be included to the study. Radioisotope will be injected via intradermal route to the breast underwent to NSM patients and lymphoscintigraphy images will be obtained to detect activity in axilla. If hot nodule is detected then it will be concluded that SLNB can be performed after NSM.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Axilla no touch | Active Comparator | Volunteer patients who did not underwent to SLNB or axillary lymph node dissection during previous NSM |
|
| Axilla with previous SLNB | Active Comparator | Volunteer patients who has underwent to SLNB but not axillary lymph node dissection during previous NSM |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Senti-Scint (99mTc- pertechnetate combined with human albumin) | Diagnostic Test | Senti-Scint will be injected via intradermal route to the breast with history of previous NSM. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Enhancement in axilla | Hot nodules will be showed in axilla after injection of SENTI-SCINT | 4 hours after injection |
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Inclusion Criteria: NSM with/without SLNB at least 6 months prior to this study -
Exclusion Criteria: previous axillary dissection and active breast cancer
-
Breast cancer is rarely seen in male patients and NSM is not performed thus study group consist of female volunteers.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Halil KARA | Contact | +905326073933 | halil.kara@acibadem.edu.tr | |
| Akif Enes Arikan | Contact | +905308222345 | enes.arikan@acibadem.com.tr |
| Name | Affiliation | Role |
|---|---|---|
| Halil KARA | Acibadem University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Acibadem Maslak Hospital | Istanbul | Sariyer | 34457 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17262724 | Background | Intra M, Veronesi P, Gentilini OD, Trifiro G, Berrettini A, Cecilio R, Colleoni M, Rietjens M, Luini A, Paganelli G, Veronesi U. Sentinel lymph node biopsy is feasible even after total mastectomy. J Surg Oncol. 2007 Feb 1;95(2):175-9. doi: 10.1002/jso.20670. | |
| 18926457 | Background | Karam A, Stempel M, Cody HS 3rd, Port ER. Reoperative sentinel lymph node biopsy after previous mastectomy. J Am Coll Surg. 2008 Oct;207(4):543-8. doi: 10.1016/j.jamcollsurg.2008.06.139. Epub 2008 Jul 21. |
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