DAnalysis of the Distribution of Adrenal Steroids in a Control Population

Analysis of the Distribution of Adrenal Steroids in Blood and Urine Measured by Mass Spectrometry Coupled to Liquid Chromatography in a Control Population

This is a biomedical research study on the determination of adrenal steroids. It has been proposed in recent years as a tool for the diagnostic orientation of an adrenal pathology. The main objective is to analyze the distribution of blood and urinary adrenal steroid values in a population of 60 controls. The secondary objective is to establish reference values for each of these parameters, if their distribution permits, and to study the possible link between the blood pressure level, the orthostatism state, the potassium level and these adrenal steroids.

Inclusion Criteria:

• Negative blood pregnancy test
• Normosalt diet
• Men and women ≥ 18 years
• Being able and willing to give written informed consent

Exclusion Criteria:

• Personal history of diabetes, high blood pressure, adrenal pathologies.
• Family history of adrenal pathologies.
• Taking of the following drugs:

Antihypertensives drugs: ACE inhibitor, Angiotensin II receptor, beta-blocker, thiazide diuretic, loop diuretic, anti-aldosterone, dihydropyridine-type calcium antagonist.

• Hormone replacement therapy, cyproterone acetate
• NSAID (except occasional intake), corticosteroid
• Antidepressant: serotonin reuptake inhibitor (paroxetine, fluoxetine, sertraline, citalopram)
• Contraception or estrogen / progestin treatment (progestins only allowed)
• Not be able to keep standing position.