This research uses the Liquid Chromatography coupled to tandem Mass Spectrometry (LC-MS / MS) technique on dried blot spot samples for the neonatal screening of congenital adrenal hyperplasia.

The main objective of this study is to demonstrate that this technique allow dosage of adrenal steroids on dried blot spot samples as efficiently and with the same sensitivity than the current technic on a cohort of 132 newborns aged 2 to 5 days, with a gestational age greater than or equal to 30 weeks of amenorrhea.

Inclusion Criteria:

• Patients aged between 48 and 120 hours of life.
• Term of gestation: 30 to 41 weeks of gestation + 6 days
• weight at inclusion ≥ 1000 g
• non-opposition of the holders of parental authority

Exclusion Criteria:

• Patient who already had neonatal screening prior to inclusion.
• Patients whose health status contraindicates additional blood collection at the time of neonatal screening.
• Inability to give legal representatives of newborns informed information
• Minor Parents

National neonatal screening covers all newborns aged between 48 and 120 hours, regardless of birth term. Premature babies born before 30 weeks of amenorrhoea are cared for in specialized neonatal or intensive care units and are intensively monitored to rule out any risk of not diagnosing HCS in a child with it. This is why our study will be conducted on a newborn population with a birth term greater than 30 weeks of amenorrhoea.