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| ID | Type | Description | Link |
|---|---|---|---|
| 2019-A01277-50 | Other Identifier | ANSM |
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Recent studies have revealed an association between history of suicide attempt and inflammatory markers in both the cerebrospinal fluid and the plasma. Post mortem studies have shown an increase in microglial activation in the brain tissue of suicide victims. However the relationship between peripheral and central inflammation in suicide is probably mediated by complex biological processes that are yet elucidated. An increase of blood S100B levels (biomarker of neurovascular damage; PMID 14530574) has been reported in adolescents with suicidal ideation vs. controls and independently of psychiatric disorder. The investigators hypothesize that peripheral inflammation may alter BBB which normally acts as a filter to ensure proper neuronal functioning in suicidal vs. non suicidal patients.
105 participants will be recruited :
Only one visit is planned. A clinical assessment (2 hours) will be performed to characterise pschopathology and suicidal characteristics. Blood and salivary samples will be obtained in order to measure inflammatory markers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Participants | Experimental | The investigator will withdraw biological samples and a biological and DNA bank will also be realized |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biological analysis | Biological | Blood and salivary samples will be taken at inclusion and a psychiatric assessment will be carried out |
|
| Measure | Description | Time Frame |
|---|---|---|
| Blood level of S100B | Blood level of S100B measured in 3 groups (i.e. suicide attempters, affective controls, healthy controls) | at inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Determination of leukocyte signature associated with suicidal behavior and depression | Comparison of the number and percentage of leukocytes (lymphocytes, monocytes, neutrophils) in the blood between the 3 patients groups | at inclusion |
| Profile of peripheral inflammation of each group |
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Inclusion Criteria:
Depending on the population :
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Philippe Courtet, MD PhD | Contact | +33 4 67 33 85 81 | p-courtet@chu-montpellier.fr | |
| Emilie Olie, MD PhD | Contact | +33 4 67 33 85 81 | e-olie@chu-montpellier.fr |
| Name | Affiliation | Role |
|---|---|---|
| Philippe Courtet, MD PhD | University Hospital, Montpellier | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University hospital | Recruiting | Montpellier | 34295 | France |
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| ID | Term |
|---|---|
| D003863 | Depression |
| D013406 | Suicide, Attempted |
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D013405 | Suicide |
| D016728 | Self-Injurious Behavior |
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| ID | Term |
|---|---|
| D057919 | Biological Oxygen Demand Analysis |
| ID | Term |
|---|---|
| D004784 | Environmental Monitoring |
| D004781 | Environmental Exposure |
| D004787 | Environmental Pollution |
| D011634 | Public Health |
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Characterization of activation state of leukocytes of CD4 / CD8 (T cells), NK cells, CD14 / CD33 (monocytes / macrophages) |
| at inclusion |
| Identification of general peripheral inflammation | Between groups comparison of blood levels of CRP | at inclusion |
| Pro-inflammatory profile based on cytokins of each group | Serum pro-inflammatory interleukins (IL) -1b, IL2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-9, IL-10, IL-12, IL-13 , TGF-b, interferon IFN-g, TNF-a, TNF-b | at inclusion |
| Profile of salivary interleukins | Profile of salivary interleukins Il-6, Il-13 et Il-17 within and between groups | at inclusion |
| Serum levels of glial fibrillary actin protein (GFAP) | Between group comparison of serum levels (ng / ml) of glial fibrillary actin protein (GFAP) | at inclusion |
| Serum levels of specific neuronal enolase (NSE) | Between group comparison of serum levels (ng / ml) of specific neuronal enolase (NSE) | at inclusion |
| Serum levels of ubiquitinar-carboxy-terminal hydrolase L1 (UCH-L1) | Between group comparison of serum levels (ng / ml) of ubiquitinar-carboxy-terminal hydrolase L1 (UCH-L1) | at inclusion |
| Salivary levels of S100B protein | Between group comparison of salivary levels of S100B protein | at inclusion |
| Salivary levels of specific neuronal enolase (NSE) | Between group comparison of salivary levels of specific neuronal enolase (NSE) in the 3 groups | at inclusion |
| Salivary levels of GFAP | Between group comparison of salivary levels of GFAP in the 3 groups | at inclusion |
| In vitro fluorescence ratio Dapi / phalloidin | The fluorescence ratio Dapi / phalloidin in a culture of neurovascular cells in the presence of the serum of the subjects (in vitro) in the 3 groups | at inclusion |
| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D004778 |
| Environment and Public Health |
| D015980 | Public Health Practice |