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| ID | Type | Description | Link |
|---|---|---|---|
| MH108857 | Other Grant/Funding Number | NIMH |
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| Name | Class |
|---|---|
| Case Western Reserve University | OTHER |
| Van Andel Research Institute | OTHER |
| National Institute of Mental Health (NIMH) | NIH |
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Suicide is one of the most devastating events in society at all levels. The primary goal of this study is to predict suicide in adolescents at risk. We will utilize blood biomarker measurement and clinical risk factor scales to develop a tool to identify adolescents at risk for suicide earlier, which will allow clinicians to prescribe timely treatment and prevent suicide.
Suicide, the second leading cause of death in adolescents (15-24 year olds), is the most tragic complication of a psychiatric condition in this age group. Every year, approximately 157,000 youth receive medical care for suicide related injuries at emergency departments throughout the U.S. Despite some progress, suicide prevention continues to be a daunting task. In adolescents, the risk of a second suicide attempt is approximately 30% after discharge from an inpatient psychiatric unit. Up to 80% of suicidal patients who subsequently died by suicide deny suicidal ideation in their last communication with a health care provider. Therefore, there is an urgent need for the development of biomarkers that can objectively identify which youth are most likely to engage in subsequent suicide attempts.
Several lines of evidence (postmortem studies, genetic studies, biomarker studies) as well as preliminary studies conducted by our group have pointed to neuroinflammation as one of the neurobiological findings observed in suicidal behavior. In particular, the principal investigator and co- investigators have identified S100B - an astrocytic protein, which is a marker of blood brain barrier (BBB) impairment, as a novel biomarker associated with suicidality in adolescents. We are now also investigating three additional and important markers Kynurenic Acid (KYNA), Quinolinic Acid (QUIN), and Picolinic Acid (PIC) identified by Dr. Lena Brundin (Van Andel Institute) to be altered in patients after a suicide attempt. Other studies have reported several other peripheral inflammatory markers (PlMs) including interleukin-1 beta (IL-1ß), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) as associated with suicidality. Hence, PlMs either on their own or along with clinical markers may be particularly useful in predicting future suicide attempts. This study will investigate whether PIM levels, with or without clinical predictors, can be useful at the time of discharge from an inpatient psychiatric unit to predict suicidality in adolescent patients in the subsequent 12 months. The first aim of this study is to determine whether plasma levels of S100B, IL-1ß, IL-6, TNF-α, KYNA, QUIN, and PIC correlate with suicidal behavior (SB). Secondly, this study will investigate if any of the PlMs can predict suicidal attempts. Finally, we will test which combination of clinical risk factors and PlMs is able to most efficiently predict SB post-discharge from the inpatient unit.
Innovative aspects of this study include: 1) The first study to longitudinally investigate levels of PlMs at the time of admission and their change at the time of discharge in adolescent patients being admitted for SB. 2) The first study to investigate whether level of PIMS (alone or in combination with clinical risk factors) at the time of discharge can predict readmissions for SB in the next 12 months. 3) Beside the well-studied PIMs in adult samples, specifically investigate novel biomarkers of inflammation- S100B and 3 markers of the Kynurenine pathway (KYNA, QUIN and PIC).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Suicide Attempt Study Group | Adolescents admitted to the Cleveland Clinic inpatient child and adolescent psychiatry unit after suicide attempt. Clinical assessments and blood samples; follow-up for 12 mos. |
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| Healthy Control Group | Healthy adolescents with no history of suicide attempt. Clinical assessments and blood samples; no 12mo follow-up. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Clinical assessments and blood samples; follow-up for 12 mos | Other | Kiddie-Sads Present and Lifetime Version Diagnostic Interview, Columbia-Suicide Severity Rating Scale, Suicidal Ideation Questionnaire, Children's Depression Rating Scale-Revised, Multidimensional Anxiety Scale for Children (2nd Ed), Adverse Childhood Experiences Questionnaire, Life Events Checklist-5, Pubertal Development Scale. All assessments administered at baseline, and a smaller subset of assessments administered at discharge and other time points throughout 12 months follow-up. Blood samples taken at baseline (admission to unit) and day of discharge. |
| Measure | Description | Time Frame |
|---|---|---|
| Relation between levels of peripheral inflammatory markers and suicide attempt | Comparison of the levels of peripheral inflammatory markers (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) between participants with and without suicide attempt | baseline |
| Relation between levels of peripheral inflammatory markers and suicide attempt | Comparison of the levels of peripheral inflammatory markers (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) between participants with and without suicide attempt | on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in peripheral inflammatory marker levels for healthy control group | Comparison of the levels of peripheral inflammatory markers (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) between baseline and discharge time points | baseline and on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
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Inclusion Criteria:
Suicide Attempt Study Group:
Healthy Control Group:
Exclusion Criteria:
Suicide Attempt Study Group:
Healthy Control Group:
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The suicide attempt study group will be recruited from all patients (ages 12-18 years) admitted to the Cleveland Clinic inpatient child and adolescent psychiatry unit after a suicide attempt. Healthy adolescent control group (ages 12-18 years) will be recruited through the Cleveland Clinic pediatric outpatient offices.
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| Name | Affiliation | Role |
|---|---|---|
| Tatiana Falcone, M.D. | The Cleveland Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Cleveland Clinic | Cleveland | Ohio | 44195 | United States |
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| ID | Term |
|---|---|
| D013406 | Suicide, Attempted |
| D059020 | Suicidal Ideation |
| D013405 | Suicide |
| D007249 | Inflammation |
| D000090862 | Neuroinflammatory Diseases |
| ID | Term |
|---|---|
| D016728 | Self-Injurious Behavior |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Plasma and serum
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| Clinical assessments and blood samples; no 12mo follow-up | Other | Kiddie-Sads Present and Lifetime Version Diagnostic Interview, Columbia-Suicide Severity Rating Scale, Suicidal Ideation Questionnaire, Children's Depression Rating Scale-Revised, Multidimensional Anxiety Scale for Children (2nd Ed), Adverse Childhood Experiences Questionnaire, Life Events Checklist-5, Pubertal Development Scale. All assessments administered at baseline, and a smaller subset of assessments administered at discharge time point (5-7 days after baseline). Blood samples taken at baseline and discharge time points (5-7 days after baseline). |
|
| Change from baseline in peripheral inflammatory marker levels for suicide attempt study group | Comparison of the levels of peripheral inflammatory markers (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) between baseline and discharge time points | baseline and on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
| Relation between levels of peripheral inflammatory markers and Columbia Suicide Severity Rating Scale scores | Studying relation between inflammatory biomarkers (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) and suicide ideation intensity (scores on Columbia Suicide Severity Rating Scale) | on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
| Relation between levels of peripheral inflammatory markers and Suicidal Ideation Questionnaire scores | Studying relation between inflammatory biomarkers (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) and suicide ideation intensity (Suicidal Ideation Questionnaire) | on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
| Relation between levels of peripheral inflammatory markers and depression | Studying relation between inflammatory biomarkers (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) and depression (scores on Children's Depression Rating Scale, Revised) | on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
| Relation between levels of peripheral inflammatory markers and anxiety | Studying relation between inflammatory biomarkers (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) and anxiety (scores on Multidimensional Anxiety Scale for Children, 2nd Ed) | on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
| Relation between levels of peripheral inflammatory markers and trauma | Studying relation between inflammatory biomarkers (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) and trauma (scores on Adverse Childhood Experiences Questionnaire (ACE) and Life Events Checklist-5 (LEC-5)) | on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
| Changes in peripheral inflammatory marker levels predicting changes in Columbia Suicide Severity Rating Scale scores | Peripheral inflammatory markers: S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid | baseline and on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
| Changes in peripheral inflammatory marker levels predicting changes in Suicidal Ideation Questionnaire scores | Peripheral inflammatory markers: S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid | baseline and on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
| Peripheral inflammatory markers as a risk factor for suicide attempts | Studying inflammatory biomarkers (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) as suicide attempt risk factors (frequency of attempts) | up to 12 months post-discharge |
| Peripheral inflammatory markers as a risk factor for suicide ideation intensity (scores on Columbia Suicide Severity Rating Scale) | Studying inflammatory biomarkers (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) as suicide ideation intensity risk factors (scores on Columbia Suicide Severity Rating Scale) | up to 12 months post-discharge |
| Peripheral inflammatory markers as a risk factor for suicide ideation intensity (scores on Suicidal Ideation Questionnaire) | Studying inflammatory biomarkers (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) as suicide ideation intensity risk factors (scores on Suicidal Ideation Questionnaire) | up to 12 months post-discharge |
| Peripheral inflammatory markers as a risk factor for suicide attempt re-admission | Studying inflammatory biomarkers (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) as suicide attempt re-admission risk factors (frequency of re-admissions) | up to 12 months post-discharge |
| Change in peripheral inflammatory marker levels from baseline to discharge as a risk factor for suicide attempts | Studying the change in inflammatory biomarkers from baseline to discharge (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) as suicide attempt risk factors (frequency of attempts) | up to 12 months post-discharge |
| Change in peripheral inflammatory marker levels from baseline to discharge as a risk factor for suicide ideation intensity (scores on Columbia Suicide Severity Rating Scale) | Studying the change in inflammatory biomarkers from baseline to discharge (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) as suicide ideation intensity risk factors (scores on Columbia Suicide Severity Rating Scale) | up to 12 months post-discharge |
| Change in peripheral inflammatory marker levels from baseline to discharge as a risk factor for suicide ideation intensity (scores on Suicidal Ideation Questionnaire) | Studying the change in inflammatory biomarkers from baseline to discharge (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) as suicide ideation intensity risk factors (scores on Suicidal Ideation Questionnaire) | up to 12 months post-discharge |
| Change in peripheral inflammatory marker levels from baseline to discharge as a risk factor for suicide attempt re-admission | Studying the change in inflammatory biomarkers from baseline to discharge (S100B, IL-6, IL-1β, TNF-α, kynurenic acid, quinolinic acid, and picolinic acid) as suicide attempt re-admission risk factors (frequency of re-admissions) | up to 12 months post-discharge |
| Clinical assessment values that predict suicide attempts | Studying which clinical assessments can help predict suicide attempt (frequency of attempts) | up to 12 months post-discharge |
| Clinical assessment values that predict suicide ideation intensity scores on Columbia Suicide Severity Rating Scale | Studying which clinical assessments can help predict suicide ideation intensity scores on Columbia Suicide Severity Rating Scale | up to 12 months post-discharge |
| Clinical assessment values that predict suicide ideation intensity scores on Suicidal Ideation Questionnaire | Studying which clinical assessments can help predict suicide ideation intensity scores on Suicidal Ideation Questionnaire | up to 12 months post-discharge |
| Clinical assessment values that predict suicide attempt re-admission | Studying which clinical assessments can help predict suicide attempt re-admission (frequency of re-admissions) | up to 12 months post-discharge |
| Peripheral inflammatory markers in combination with clinical assessments as predictors for suicide attempts | Studying which combination of inflammatory biomarkers and clinical predictors best predicts future suicide attempts (frequency of attempts) | up to 12 months post-discharge |
| Peripheral inflammatory markers in combination with clinical assessments as predictors for suicide ideation intensity scores on Columbia Suicide Severity Rating Scale | Studying which combination of inflammatory biomarkers and clinical predictors best predicts suicide ideation intensity scores on Columbia Suicide Severity Rating Scale | up to 12 months post-discharge |
| Peripheral inflammatory markers in combination with clinical assessments as predictors for suicide ideation intensity scores on Suicidal Ideation Questionnaire | Studying which combination of inflammatory biomarkers and clinical predictors best predicts suicide ideation intensity scores on Suicidal Ideation Questionnaire | up to 12 months post-discharge |
| Peripheral inflammatory markers in combination with clinical assessments as predictors for suicide attempt re-admission | Studying which combination of inflammatory biomarkers and clinical predictors best predicts future suicide attempt re-admissions (frequency of re-admissions) | up to 12 months post-discharge |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D009422 | Nervous System Diseases |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |